This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3jsp

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:13, 21 February 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3jsp.png|left|200px]]
 
-
<!--
+
==Classic Protein With a New Twist: crystal structure of a LexA repressor DNA complex==
-
The line below this paragraph, containing "STRUCTURE_3jsp", creates the "Structure Box" on the page.
+
<StructureSection load='3jsp' size='340' side='right'caption='[[3jsp]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3jsp]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3JSP FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3jsp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3jsp OCA], [https://pdbe.org/3jsp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3jsp RCSB], [https://www.ebi.ac.uk/pdbsum/3jsp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3jsp ProSAT]</span></td></tr>
-
{{STRUCTURE_3jsp| PDB=3jsp | SCENE= }}
+
</table>
-
 
+
== Function ==
-
===Classic Protein With a New Twist: crystal structure of a LexA repressor DNA complex===
+
[https://www.uniprot.org/uniprot/LEXA_ECOLI LEXA_ECOLI] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. Binds to the 16 bp palindromic sequence 5'-CTGTATATATATACAG-3'. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair.<ref>PMID:7027255</ref> <ref>PMID:7027256</ref>
-
 
+
== Evolutionary Conservation ==
-
 
+
[[Image:Consurf_key_small.gif|200px|right]]
-
<!--
+
Check<jmol>
-
The line below this paragraph, {{ABSTRACT_PUBMED_20703307}}, adds the Publication Abstract to the page
+
<jmolCheckbox>
-
(as it appears on PubMed at http://www.pubmed.gov), where 20703307 is the PubMed ID number.
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/js/3jsp_consurf.spt"</scriptWhenChecked>
-
-->
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
{{ABSTRACT_PUBMED_20703307}}
+
<text>to colour the structure by Evolutionary Conservation</text>
-
 
+
</jmolCheckbox>
-
==About this Structure==
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3jsp ConSurf].
-
[[3jsp]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3JSP OCA].
+
<div style="clear:both"></div>
-
 
+
== References ==
-
==Reference==
+
<references/>
-
<ref group="xtra">PMID:020703307</ref><references group="xtra"/>
+
__TOC__
-
[[Category: Escherichia coli k-12]]
+
</StructureSection>
-
[[Category: Repressor lexA]]
+
[[Category: Escherichia coli K-12]]
-
[[Category: Pigli, Y Z.]]
+
[[Category: Large Structures]]
-
[[Category: Rice, P A.]]
+
[[Category: Pigli YZ]]
-
[[Category: Zhang, A P.P.]]
+
[[Category: Rice PA]]
-
[[Category: Autocatalytic cleavage]]
+
[[Category: Zhang APP]]
-
[[Category: Dna damage]]
+
-
[[Category: Dna repair]]
+
-
[[Category: Dna replication]]
+
-
[[Category: Dna-binding]]
+
-
[[Category: Double helix]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Hydrolase-dna complex]]
+
-
[[Category: Lexa]]
+
-
[[Category: Protein-dna complex]]
+
-
[[Category: Repressor]]
+
-
[[Category: Sos response]]
+
-
[[Category: Sos system]]
+
-
[[Category: Transcription]]
+
-
[[Category: Transcription regulation]]
+
-
[[Category: Winged helix-turn-helix]]
+

Current revision

Classic Protein With a New Twist: crystal structure of a LexA repressor DNA complex

PDB ID 3jsp

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3jsp"
Personal tools