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3kbl

From Proteopedia

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{{STRUCTURE_3kbl| PDB=3kbl | SCENE= }}
 
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===Crystal structure of the GLD-1 homodimerization domain from Caenorhabditis elegans N169A mutant at 2.28 A resolution===
 
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{{ABSTRACT_PUBMED_20223220}}
 
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==Function==
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==Crystal structure of the GLD-1 homodimerization domain from Caenorhabditis elegans N169A mutant at 2.28 A resolution==
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[[http://www.uniprot.org/uniprot/GLD1_CAEEL GLD1_CAEEL]] Germ line-specific tumor suppressor essential for oogenesis. Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pachytene) and then derepression of translation during diplotene/ diakinesis, following its degradation. Also functions to promote the male sexual fate in the hermaphrodite germline but not the male germline. Functions redundantly with gld-2 to promote the initiation of meiotic development and/or inhibit stem cell proliferation.
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<StructureSection load='3kbl' size='340' side='right'caption='[[3kbl]], [[Resolution|resolution]] 2.28&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3kbl]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KBL FirstGlance]. <br>
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[[3kbl]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Caenorhabditis_elegans Caenorhabditis elegans]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KBL OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.28&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kbl OCA], [https://pdbe.org/3kbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kbl RCSB], [https://www.ebi.ac.uk/pdbsum/3kbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kbl ProSAT]</span></td></tr>
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==Reference==
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</table>
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<ref group="xtra">PMID:020223220</ref><references group="xtra"/><references/>
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== Function ==
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[https://www.uniprot.org/uniprot/GLD1_CAEEL GLD1_CAEEL] Germ line-specific tumor suppressor essential for oogenesis. Controls the spatial pattern of translation of multiple oogenesis specific mRNAs (e.g. yolk receptor rme-2) by repression of translation during early meiotic prophase (leptotene to pachytene) and then derepression of translation during diplotene/ diakinesis, following its degradation. Also functions to promote the male sexual fate in the hermaphrodite germline but not the male germline. Functions redundantly with gld-2 to promote the initiation of meiotic development and/or inhibit stem cell proliferation.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/3kbl_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kbl ConSurf].
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
[[Category: Caenorhabditis elegans]]
[[Category: Caenorhabditis elegans]]
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[[Category: Beuck, C.]]
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[[Category: Large Structures]]
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[[Category: Carmel, A B.]]
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[[Category: Beuck C]]
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[[Category: Columbus, L.]]
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[[Category: Carmel AB]]
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[[Category: Kerkow, D E.]]
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[[Category: Columbus L]]
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[[Category: Stanfield, R L.]]
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[[Category: Kerkow DE]]
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[[Category: Szymczyna, B R.]]
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[[Category: Stanfield RL]]
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[[Category: Williamson, J R.]]
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[[Category: Szymczyna BR]]
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[[Category: Developmental protein]]
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[[Category: Williamson JR]]
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[[Category: Differentiation]]
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[[Category: Gld-1]]
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[[Category: Helix-turn-helix motif]]
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[[Category: Hydrophobic homodimer interface]]
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[[Category: Meiosis]]
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[[Category: N169a mutant]]
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[[Category: Oogenesis]]
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[[Category: Perpendicular stacking of protomer]]
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[[Category: Protein binding]]
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[[Category: Qua1 homodimerization domain]]
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[[Category: Rna-binding]]
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[[Category: Translation regulation]]
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Current revision

Crystal structure of the GLD-1 homodimerization domain from Caenorhabditis elegans N169A mutant at 2.28 A resolution

PDB ID 3kbl

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