This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3kt9

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:18, 21 February 2024) (edit) (undo)
 
(5 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3kt9.png|left|200px]]
 
-
<!--
+
==Aprataxin FHA Domain==
-
The line below this paragraph, containing "STRUCTURE_3kt9", creates the "Structure Box" on the page.
+
<StructureSection load='3kt9' size='340' side='right'caption='[[3kt9]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3kt9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KT9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KT9 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kt9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kt9 OCA], [https://pdbe.org/3kt9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kt9 RCSB], [https://www.ebi.ac.uk/pdbsum/3kt9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kt9 ProSAT]</span></td></tr>
-
{{STRUCTURE_3kt9| PDB=3kt9 | SCENE= }}
+
</table>
-
 
+
== Disease ==
-
===Aprataxin FHA Domain===
+
[https://www.uniprot.org/uniprot/APTX_HUMAN APTX_HUMAN] Defects in APTX are the cause of ataxia-oculomotor apraxia syndrome (AOA) [MIM:[https://omim.org/entry/208920 208920]. AOA is an autosomal recessive syndrome characterized by early-onset cerebellar ataxia, oculomotor apraxia, early areflexia and late peripheral neuropathy.<ref>PMID:11586299</ref> <ref>PMID:11586300</ref> <ref>PMID:12196655</ref> <ref>PMID:12629250</ref> <ref>PMID:14506070</ref> <ref>PMID:15852392</ref> <ref>PMID:15699391</ref>
-
 
+
== Function ==
-
 
+
[https://www.uniprot.org/uniprot/APTX_HUMAN APTX_HUMAN] DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH(2)) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity.<ref>PMID:14755728</ref> <ref>PMID:15044383</ref> <ref>PMID:16547001</ref> <ref>PMID:16964241</ref> <ref>PMID:17276982</ref>
-
<!--
+
== Evolutionary Conservation ==
-
The line below this paragraph, {{ABSTRACT_PUBMED_20008512}}, adds the Publication Abstract to the page
+
[[Image:Consurf_key_small.gif|200px|right]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 20008512 is the PubMed ID number.
+
Check<jmol>
-
-->
+
<jmolCheckbox>
-
{{ABSTRACT_PUBMED_20008512}}
+
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kt/3kt9_consurf.spt"</scriptWhenChecked>
-
 
+
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-
==About this Structure==
+
<text>to colour the structure by Evolutionary Conservation</text>
-
3KT9 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KT9 OCA].
+
</jmolCheckbox>
-
 
+
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kt9 ConSurf].
-
==Reference==
+
<div style="clear:both"></div>
-
<ref group="xtra">PMID:20008512</ref><references group="xtra"/>
+
== References ==
 +
<references/>
 +
__TOC__
 +
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Cherry, A L.]]
+
[[Category: Large Structures]]
-
[[Category: Smerdon, S J.]]
+
[[Category: Cherry AL]]
-
[[Category: Alternative splicing]]
+
[[Category: Smerdon SJ]]
-
[[Category: Amp hydrolase]]
+
-
[[Category: Beta sandwich]]
+
-
[[Category: Beta sheet]]
+
-
[[Category: Disease mutation]]
+
-
[[Category: Dna damage]]
+
-
[[Category: Dna repair]]
+
-
[[Category: Dna-binding]]
+
-
[[Category: Fha domain]]
+
-
[[Category: Hydrolase]]
+
-
[[Category: Metal-binding]]
+
-
[[Category: Neurodegeneration]]
+
-
[[Category: Nucleus]]
+
-
[[Category: Zinc]]
+
-
[[Category: Zinc-finger]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Mar 24 08:24:50 2010''
+

Current revision

Aprataxin FHA Domain

PDB ID 3kt9

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3kt9"
Personal tools