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3kzd

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{{Seed}}
 
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[[Image:3kzd.png|left|200px]]
 
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==Crystal Structure of Free T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain==
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The line below this paragraph, containing "STRUCTURE_3kzd", creates the "Structure Box" on the page.
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<StructureSection load='3kzd' size='340' side='right'caption='[[3kzd]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3kzd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KZD FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kzd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kzd OCA], [https://pdbe.org/3kzd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kzd RCSB], [https://www.ebi.ac.uk/pdbsum/3kzd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kzd ProSAT]</span></td></tr>
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{{STRUCTURE_3kzd| PDB=3kzd | SCENE= }}
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</table>
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== Function ==
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===Crystal Structure of Free T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain===
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[https://www.uniprot.org/uniprot/TIAM1_HUMAN TIAM1_HUMAN] Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP-dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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The line below this paragraph, {{ABSTRACT_PUBMED_20361982}}, adds the Publication Abstract to the page
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<jmolCheckbox>
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(as it appears on PubMed at http://www.pubmed.gov), where 20361982 is the PubMed ID number.
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kz/3kzd_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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{{ABSTRACT_PUBMED_20361982}}
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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==About this Structure==
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3kzd ConSurf].
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3KZD is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KZD OCA].
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<div style="clear:both"></div>
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:20361982</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fuentes, E J.]]
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[[Category: Large Structures]]
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[[Category: Shepherd, T R.]]
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[[Category: Fuentes EJ]]
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[[Category: Cell adhesion]]
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[[Category: Shepherd TR]]
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[[Category: Cell junction]]
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[[Category: Guanine nucleotide exchange factor]]
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[[Category: Guanine-nucleotide releasing factor]]
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[[Category: Lipoprotein]]
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[[Category: Myristate]]
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[[Category: Pdz]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Signaling protein]]
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[[Category: Tiam1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:06:03 2010''
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Current revision

Crystal Structure of Free T-cell Lymphoma Invasion and Metastasis-1 PDZ Domain

PDB ID 3kzd

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