3l0j

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{{Seed}}
 
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[[Image:3l0j.png|left|200px]]
 
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==Crystal structure of orphan nuclear receptor RORgamma in complex with natural ligand==
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The line below this paragraph, containing "STRUCTURE_3l0j", creates the "Structure Box" on the page.
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<StructureSection load='3l0j' size='340' side='right'caption='[[3l0j]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3l0j]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L0J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HC9:(3ALPHA,8ALPHA,22R)-CHOLEST-5-ENE-3,22-DIOL'>HC9</scene></td></tr>
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{{STRUCTURE_3l0j| PDB=3l0j | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l0j OCA], [https://pdbe.org/3l0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l0j RCSB], [https://www.ebi.ac.uk/pdbsum/3l0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l0j ProSAT]</span></td></tr>
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</table>
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===Crystal structure of orphan nuclear receptor RORgamma in complex with natural ligand===
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== Function ==
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[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l0/3l0j_consurf.spt"</scriptWhenChecked>
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{{ABSTRACT_PUBMED_20203100}}
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==About this Structure==
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</jmolCheckbox>
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3L0J is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L0J OCA].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l0j ConSurf].
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<div style="clear:both"></div>
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==Reference==
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__TOC__
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<ref group="xtra">PMID:20203100</ref><references group="xtra"/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Li, Y.]]
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[[Category: Large Structures]]
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[[Category: Martynowski, D.]]
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[[Category: Li Y]]
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[[Category: Acetylation]]
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[[Category: Martynowski D]]
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[[Category: Activator]]
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[[Category: Alternative splicing]]
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[[Category: Dna-binding]]
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[[Category: Metal-binding]]
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[[Category: Nuclear receptor]]
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[[Category: Nucleus]]
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[[Category: Phosphoprotein]]
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[[Category: Polymorphism]]
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[[Category: Receptor]]
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[[Category: Ror gamma]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:31:44 2010''
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Current revision

Crystal structure of orphan nuclear receptor RORgamma in complex with natural ligand

PDB ID 3l0j

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