3l81
From Proteopedia
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| - | [[Image:3l81.png|left|200px]] | ||
| - | + | ==Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP)== | |
| - | + | <StructureSection load='3l81' size='340' side='right'caption='[[3l81]], [[Resolution|resolution]] 1.60Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3l81]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L81 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L81 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr> | |
| - | == | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l81 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l81 OCA], [https://pdbe.org/3l81 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l81 RCSB], [https://www.ebi.ac.uk/pdbsum/3l81 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l81 ProSAT]</span></td></tr> |
| - | [[3l81]] is a 2 chain structure | + | </table> |
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/AP4M1_HUMAN AP4M1_HUMAN] Defects in AP4M1 are the cause of cerebral palsy spastic quadriplegic type 3 (CPSQ3) [MIM:[https://omim.org/entry/612936 612936]. A non-progressive disorder of movement and/or posture resulting from defects in the developing central nervous system. Affected individuals present postnatally with early infantile hypotonia, delayed psychomotor development, strabismus, lack of independent walking and severe mental retardation. They develop progressive spasticity of all limbs with generalized hypertonia, hyperreflexia, and extensor plantar responses by the end of the first year of life. Speech is absent or limited. Pseudobulbar signs, such as drooling, stereotypic laughter, and exaggerated jaw jerk, are part of the clinical picture. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/AP4M1_HUMAN AP4M1_HUMAN] Subunit of novel type of clathrin- or non-clathrin-associated protein coat involved in targeting proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. | ||
| + | == Evolutionary Conservation == | ||
| + | [[Image:Consurf_key_small.gif|200px|right]] | ||
| + | Check<jmol> | ||
| + | <jmolCheckbox> | ||
| + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l8/3l81_consurf.spt"</scriptWhenChecked> | ||
| + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
| + | <text>to colour the structure by Evolutionary Conservation</text> | ||
| + | </jmolCheckbox> | ||
| + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l81 ConSurf]. | ||
| + | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Amyloid precursor protein|Amyloid precursor protein]] | + | *[[Adaptin 3D structures|Adaptin 3D structures]] |
| - | + | *[[Amyloid precursor protein 3D structures|Amyloid precursor protein 3D structures]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: Bonifacino | + | [[Category: Large Structures]] |
| - | [[Category: Burgos | + | [[Category: Bonifacino JS]] |
| - | [[Category: Dasilva | + | [[Category: Burgos PV]] |
| - | [[Category: Hurley | + | [[Category: Dasilva LLP]] |
| - | [[Category: Mardones | + | [[Category: Hurley JH]] |
| - | [[Category: Prabhu | + | [[Category: Mardones GA]] |
| - | [[Category: Rojas | + | [[Category: Prabhu Y]] |
| - | + | [[Category: Rojas AL]] | |
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Current revision
Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain, in complex with a sorting peptide from the amyloid precursor protein (APP)
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