This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
3lcr
From Proteopedia
(Difference between revisions)
| (4 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| - | {{Seed}} | ||
| - | [[Image:3lcr.png|left|200px]] | ||
| - | + | ==Thioesterase from Tautomycetin Biosynthhetic Pathway== | |
| - | + | <StructureSection load='3lcr' size='340' side='right'caption='[[3lcr]], [[Resolution|resolution]] 2.00Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3lcr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_sp._CK4412 Streptomyces sp. CK4412]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LCR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LCR FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lcr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lcr OCA], [https://pdbe.org/3lcr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lcr RCSB], [https://www.ebi.ac.uk/pdbsum/3lcr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lcr ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/A4KCE5_9ACTN A4KCE5_9ACTN] Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain.[ARBA:ARBA00023442] | |
| - | + | == Evolutionary Conservation == | |
| - | == | + | [[Image:Consurf_key_small.gif|200px|right]] |
| - | + | Check<jmol> | |
| - | + | <jmolCheckbox> | |
| - | == | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lc/3lcr_consurf.spt"</scriptWhenChecked> |
| - | < | + | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> |
| - | [[ | + | <text>to colour the structure by Evolutionary Conservation</text> |
| - | [ | + | </jmolCheckbox> |
| - | [ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lcr ConSurf]. |
| - | [[ | + | <div style="clear:both"></div> |
| - | [ | + | __TOC__ |
| - | [[ | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Streptomyces sp. CK4412]] |
| - | [[Category: | + | [[Category: Akey DL]] |
| - | [[Category: | + | [[Category: Scaglione JB]] |
| - | [[Category: | + | [[Category: Sherman DH]] |
| - | + | [[Category: Smith JL]] | |
| - | + | ||
Current revision
Thioesterase from Tautomycetin Biosynthhetic Pathway
| |||||||||||
