This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3lue

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (10:22, 21 February 2024) (edit) (undo)
 
(11 intermediate revisions not shown.)
Line 1: Line 1:
-
{{Seed}}
 
-
[[Image:3lue.jpg|left|200px]]
 
-
<!--
+
==Model of alpha-actinin CH1 bound to F-actin==
-
The line below this paragraph, containing "STRUCTURE_3lue", creates the "Structure Box" on the page.
+
<SX load='3lue' size='340' side='right' viewer='molstar' caption='[[3lue]], [[Resolution|resolution]] 15.00&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3lue]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LUE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LUE FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 15&#8491;</td></tr>
-
-->
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3lue FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lue OCA], [https://pdbe.org/3lue PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3lue RCSB], [https://www.ebi.ac.uk/pdbsum/3lue PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3lue ProSAT]</span></td></tr>
-
{{STRUCTURE_3lue| PDB=3lue | SCENE= }}
+
</table>
 +
== Disease ==
 +
[https://www.uniprot.org/uniprot/ACTB_HUMAN ACTB_HUMAN] Defects in ACTB are a cause of dystonia juvenile-onset (DYTJ) [MIM:[https://omim.org/entry/607371 607371]. DYTJ is a form of dystonia with juvenile onset. Dystonia is defined by the presence of sustained involuntary muscle contraction, often leading to abnormal postures. DYTJ patients manifest progressive, generalized, dopa-unresponsive dystonia, developmental malformations and sensory hearing loss.<ref>PMID:16685646</ref> Defects in ACTB are the cause of Baraitser-Winter syndrome type 1 (BRWS1) [MIM:[https://omim.org/entry/243310 243310]. A rare developmental disorder characterized by the combination of congenital ptosis, high-arched eyebrows, hypertelorism, ocular colobomata, and a brain malformation consisting of anterior-predominant lissencephaly. Other typical features include postnatal short stature and microcephaly, intellectual disability, seizures, and hearing loss.<ref>PMID:22366783</ref>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/ACTB_HUMAN ACTB_HUMAN] Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
 +
== Evolutionary Conservation ==
 +
[[Image:Consurf_key_small.gif|200px|right]]
 +
Check<jmol>
 +
<jmolCheckbox>
 +
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lu/3lue_consurf.spt"</scriptWhenChecked>
 +
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
 +
<text>to colour the structure by Evolutionary Conservation</text>
 +
</jmolCheckbox>
 +
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lue ConSurf].
 +
<div style="clear:both"></div>
-
===Model of alpha-actinin CH1 bound to F-actin===
+
==See Also==
-
 
+
*[[Actin 3D structures|Actin 3D structures]]
-
 
+
*[[Actinin 3D structures|Actinin 3D structures]]
-
<!--
+
== References ==
-
The line below this paragraph, {{ABSTRACT_PUBMED_20383143}}, adds the Publication Abstract to the page
+
<references/>
-
(as it appears on PubMed at http://www.pubmed.gov), where 20383143 is the PubMed ID number.
+
__TOC__
-
-->
+
</SX>
-
{{ABSTRACT_PUBMED_20383143}}
+
-
 
+
-
==Disease==
+
-
Known disease associated with this structure: Dystonia, juvenile-onset OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=102630 102630]], Alpha-actinin-3 deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=102574 102574]], Sprinting performance OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=102574 102574]]
+
-
 
+
-
==About this Structure==
+
-
3LUE is a 20 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LUE OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:20383143</ref><references group="xtra"/>
+
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
-
[[Category: Djinovic-Carugo, K.]]
+
[[Category: Large Structures]]
-
[[Category: Egelman, E H.]]
+
[[Category: Djinovic-Carugo K]]
-
[[Category: Galkin, V E.]]
+
[[Category: Egelman EH]]
-
[[Category: Orlova, A.]]
+
[[Category: Galkin VE]]
-
[[Category: Salmazo, A.]]
+
[[Category: Orlova A]]
-
[[Category: Acetylation]]
+
[[Category: Salmazo A]]
-
[[Category: Actin-binding]]
+
-
[[Category: Atp-binding]]
+
-
[[Category: Calcium]]
+
-
[[Category: Calponin homology domain]]
+
-
[[Category: Cytoplasm]]
+
-
[[Category: Cytoskeleton]]
+
-
[[Category: Deafness]]
+
-
[[Category: Disease mutation]]
+
-
[[Category: Dystonia]]
+
-
[[Category: Methylation]]
+
-
[[Category: Nucleotide-binding]]
+
-
[[Category: Phosphoprotein]]
+
-
[[Category: Polymorphism]]
+
-
[[Category: Structural protein]]
+
-
 
+
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 10:59:42 2010''
+

Current revision

Model of alpha-actinin CH1 bound to F-actin

3lue, resolution 15.00Å

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3lue"
Personal tools