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3m6a

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{{STRUCTURE_3m6a| PDB=3m6a | SCENE= }}
 
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===Crystal structure of Bacillus subtilis Lon C-terminal domain===
 
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{{ABSTRACT_PUBMED_20600124}}
 
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==Function==
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==Crystal structure of Bacillus subtilis Lon C-terminal domain==
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[[http://www.uniprot.org/uniprot/LON1_BACSU LON1_BACSU]] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). Has been implicated in preventing sigma(G) activity under non-sporulation conditions.[HAMAP-Rule:MF_01973]
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<StructureSection load='3m6a' size='340' side='right'caption='[[3m6a]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3m6a]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis_subsp._subtilis_str._168 Bacillus subtilis subsp. subtilis str. 168]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M6A FirstGlance]. <br>
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[[3m6a]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M6A OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m6a OCA], [https://pdbe.org/3m6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m6a RCSB], [https://www.ebi.ac.uk/pdbsum/3m6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m6a ProSAT]</span></td></tr>
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<ref group="xtra">PMID:020600124</ref><references group="xtra"/><references/>
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</table>
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[[Category: Bacillus subtilis]]
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== Function ==
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[[Category: Endopeptidase La]]
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[https://www.uniprot.org/uniprot/LON1_BACSU LON1_BACSU] ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity). Has been implicated in preventing sigma(G) activity under non-sporulation conditions.[HAMAP-Rule:MF_01973]
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[[Category: Duman, R E.]]
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== Evolutionary Conservation ==
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[[Category: Lowe, J Y.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Alpha]]
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Check<jmol>
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[[Category: Atp-binding]]
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<jmolCheckbox>
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[[Category: Beta]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m6/3m6a_consurf.spt"</scriptWhenChecked>
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[[Category: Hydrolase]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Nucleotide-binding]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Protease]]
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</jmolCheckbox>
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[[Category: Serine protease]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m6a ConSurf].
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[[Category: Stress response]]
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<div style="clear:both"></div>
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__TOC__
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</StructureSection>
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[[Category: Bacillus subtilis subsp. subtilis str. 168]]
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[[Category: Large Structures]]
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[[Category: Duman RE]]
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[[Category: Lowe JY]]

Current revision

Crystal structure of Bacillus subtilis Lon C-terminal domain

PDB ID 3m6a

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