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3mz6

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{{Seed}}
 
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[[Image:3mz6.jpg|left|200px]]
 
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==Crystal structure of D101L Fe2+ HDAC8 complexed with M344==
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The line below this paragraph, containing "STRUCTURE_3mz6", creates the "Structure Box" on the page.
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<StructureSection load='3mz6' size='340' side='right'caption='[[3mz6]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3mz6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MZ6 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B3N:4-(DIMETHYLAMINO)-N-[7-(HYDROXYAMINO)-7-OXOHEPTYL]BENZAMIDE'>B3N</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr>
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{{STRUCTURE_3mz6| PDB=3mz6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mz6 OCA], [https://pdbe.org/3mz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mz6 RCSB], [https://www.ebi.ac.uk/pdbsum/3mz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mz6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/HDAC8_HUMAN HDAC8_HUMAN] Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. May play a role in smooth muscle cell contractility.<ref>PMID:10748112</ref> <ref>PMID:10926844</ref> <ref>PMID:10922473</ref> <ref>PMID:14701748</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mz/3mz6_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mz6 ConSurf].
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<div style="clear:both"></div>
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===Crystal structure of D101L Fe2+ HDAC8 complexed with M344===
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==See Also==
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*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20545365 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_20545365}}
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==About this Structure==
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3MZ6 is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MZ6 OCA].
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==Reference==
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<ref group="xtra">PMID:20545365</ref><references group="xtra"/>
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[[Category: Histone deacetylase]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Christianson, D W.]]
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[[Category: Large Structures]]
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[[Category: Dowling, D P.]]
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[[Category: Christianson DW]]
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[[Category: Fierke, C A.]]
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[[Category: Dowling DP]]
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[[Category: Gattis, S G.]]
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[[Category: Fierke CA]]
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[[Category: Arginase-fold]]
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[[Category: Gattis SG]]
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[[Category: Ferrous]]
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[[Category: Hydrolase]]
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[[Category: Metallohydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:53:04 2010''
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Current revision

Crystal structure of D101L Fe2+ HDAC8 complexed with M344

PDB ID 3mz6

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