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3ny3

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{{Seed}}
 
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[[Image:3ny3.png|left|200px]]
 
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==Structure of the ubr-box of UBR2 in complex with N-degron==
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The line below this paragraph, containing "STRUCTURE_3ny3", creates the "Structure Box" on the page.
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<StructureSection load='3ny3' size='340' side='right'caption='[[3ny3]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ny3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NY3 FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3ny3| PDB=3ny3 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ny3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ny3 OCA], [https://pdbe.org/3ny3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ny3 RCSB], [https://www.ebi.ac.uk/pdbsum/3ny3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ny3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/UBR2_HUMAN UBR2_HUMAN] E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth.<ref>PMID:15548684</ref> <ref>PMID:20298436</ref> <ref>PMID:20835242</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/3ny3_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ny3 ConSurf].
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<div style="clear:both"></div>
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===Structure of the ubr-box of UBR2 in complex with N-degron===
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==See Also==
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*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 20835242 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_20835242}}
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==About this Structure==
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3NY3 is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NY3 OCA].
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==Reference==
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<ref group="xtra">PMID:20835242</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Ubiquitin--protein ligase]]
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[[Category: Large Structures]]
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[[Category: Gehring, K.]]
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[[Category: Gehring K]]
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[[Category: Kozlov, G.]]
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[[Category: Kozlov G]]
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[[Category: Li, F.]]
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[[Category: Li F]]
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[[Category: Matta-Camacho, E.]]
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[[Category: Matta-Camacho E]]
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[[Category: Ligase]]
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[[Category: Lygase]]
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[[Category: Protein binding]]
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[[Category: Ubiquitin ligase]]
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[[Category: Zinc finger-like]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 20 06:11:21 2010''
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Current revision

Structure of the ubr-box of UBR2 in complex with N-degron

PDB ID 3ny3

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