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3nyn

From Proteopedia

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{{STRUCTURE_3nyn| PDB=3nyn | SCENE= }}
 
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===Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with Sangivamycin===
 
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{{ABSTRACT_PUBMED_20729810}}
 
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==Function==
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==Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with Sangivamycin==
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[[http://www.uniprot.org/uniprot/GRK6_HUMAN GRK6_HUMAN]] Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).<ref>PMID:19801552</ref> <ref>PMID:20048153</ref>
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<StructureSection load='3nyn' size='340' side='right'caption='[[3nyn]], [[Resolution|resolution]] 2.72&Aring;' scene=''>
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== Structural highlights ==
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==About this Structure==
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<table><tr><td colspan='2'>[[3nyn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NYN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NYN FirstGlance]. <br>
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[[3nyn]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NYN OCA].
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.72&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=BU3:(R,R)-2,3-BUTANEDIOL'>BU3</scene>, <scene name='pdbligand=SGV:SANGIVAMYCIN'>SGV</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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==Reference==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nyn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nyn OCA], [https://pdbe.org/3nyn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nyn RCSB], [https://www.ebi.ac.uk/pdbsum/3nyn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nyn ProSAT]</span></td></tr>
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<ref group="xtra">PMID:020729810</ref><references group="xtra"/><references/>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GRK6_HUMAN GRK6_HUMAN] Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis (By similarity). Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor: LRP6 during Wnt signaling (in vitro).<ref>PMID:19801552</ref> <ref>PMID:20048153</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ny/3nyn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nyn ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Singh, P.]]
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[[Category: Large Structures]]
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[[Category: Tesmer, J J.G.]]
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[[Category: Singh P]]
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[[Category: G protein-coupled receptor kinase]]
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[[Category: Tesmer JJG]]
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[[Category: Grk]]
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[[Category: Kinase]]
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[[Category: Rgs homology domain]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of G Protein-Coupled Receptor Kinase 6 in Complex with Sangivamycin

PDB ID 3nyn

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