3o0j

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[[Image:3o0j.png|left|200px]]
 
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==PDE4B In complex with ligand an2898==
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The line below this paragraph, containing "STRUCTURE_3o0j", creates the "Structure Box" on the page.
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<StructureSection load='3o0j' size='340' side='right'caption='[[3o0j]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3o0j]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O0J FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3OJ:4-[(1-HYDROXY-1,3-DIHYDRO-2,1-BENZOXABOROL-5-YL)OXY]BENZENE-1,2-DICARBONITRILE'>3OJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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{{STRUCTURE_3o0j| PDB=3o0j | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o0j OCA], [https://pdbe.org/3o0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o0j RCSB], [https://www.ebi.ac.uk/pdbsum/3o0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o0j ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE4B_HUMAN PDE4B_HUMAN] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents.<ref>PMID:10846163</ref> <ref>PMID:15003452</ref>
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===PDE4B In complex with ligand an2898===
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3o0j]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O0J OCA].
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__TOC__
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[[Category: 3',5'-cyclic-nucleotide phosphodiesterase]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Alley, M R.K.]]
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[[Category: Large Structures]]
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[[Category: Zhou, Y.]]
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[[Category: Alley MRK]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Zhou Y]]
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[[Category: Phosphodiesterase]]
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Current revision

PDE4B In complex with ligand an2898

PDB ID 3o0j

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