3o8h

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{{STRUCTURE_3o8h| PDB=3o8h | SCENE= }}
 
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===EthR from Mycobacterium tuberculosis in complex with compound BDM14950===
 
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{{ABSTRACT_PUBMED_20704273}}
 
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==Function==
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==EthR from Mycobacterium tuberculosis in complex with compound BDM14950==
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[[http://www.uniprot.org/uniprot/P96222_MYCTU P96222_MYCTU]] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
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<StructureSection load='3o8h' size='340' side='right'caption='[[3o8h]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3o8h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O8H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3O8H FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=O8H:4-IODO-N-[(1-{2-OXO-2-[4-(3-THIOPHEN-2-YL-1,2,4-OXADIAZOL-5-YL)PIPERIDIN-1-YL]ETHYL}-1H-1,2,3-TRIAZOL-4-YL)METHYL]BENZENESULFONAMIDE'>O8H</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3o8h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3o8h OCA], [https://pdbe.org/3o8h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3o8h RCSB], [https://www.ebi.ac.uk/pdbsum/3o8h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3o8h ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/o8/3o8h_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3o8h ConSurf].
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<div style="clear:both"></div>
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==About this Structure==
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==See Also==
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[[3o8h]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3O8H OCA].
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*[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020704273</ref><references group="xtra"/><references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Baulard, A.]]
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[[Category: Baulard A]]
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[[Category: Deprez, B.]]
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[[Category: Deprez B]]
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[[Category: Desroses, M.]]
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[[Category: Desroses M]]
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[[Category: Diri, B.]]
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[[Category: Diri B]]
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[[Category: Lens, Z.]]
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[[Category: Lens Z]]
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[[Category: Locht, C.]]
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[[Category: Locht C]]
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[[Category: Rucktooa, P.]]
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[[Category: Rucktooa P]]
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[[Category: Toto, P.]]
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[[Category: Toto P]]
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[[Category: Villeret, V.]]
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[[Category: Villeret V]]
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[[Category: Willand, N.]]
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[[Category: Willand N]]
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[[Category: Dna]]
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[[Category: Tetr-family]]
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[[Category: Transcription]]
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[[Category: Transcriptional regulatory repressor]]
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Current revision

EthR from Mycobacterium tuberculosis in complex with compound BDM14950

PDB ID 3o8h

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