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3oxh

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[[Image:3oxh.png|left|200px]]
 
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==Mycobacterium tuberculosis kinase inhibitor homolog RV0577==
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The line below this paragraph, containing "STRUCTURE_3oxh", creates the "Structure Box" on the page.
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<StructureSection load='3oxh' size='340' side='right'caption='[[3oxh]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3oxh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OXH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OXH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PMB:PARA-MERCURY-BENZENESULFONIC+ACID'>PMB</scene>, <scene name='pdbligand=XYL:D-XYLITOL'>XYL</scene></td></tr>
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{{STRUCTURE_3oxh| PDB=3oxh | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oxh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oxh OCA], [https://pdbe.org/3oxh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oxh RCSB], [https://www.ebi.ac.uk/pdbsum/3oxh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oxh ProSAT]</span></td></tr>
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</table>
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===Mycobacterium tuberculosis kinase inhibitor homolog RV0577===
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== Function ==
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[https://www.uniprot.org/uniprot/CFP32_MYCTU CFP32_MYCTU] May function as a glyoxylase involved in the methylglyoxal detoxification pathway (PubMed:20975714). Induces maturation of dendritic cells in a TLR2-dependent manner, causing increased expression of cell-surface molecules (CD80, CD86, MHC class I and II) and pro-inflammatory cytokines (TNF-alpha, IL-6, IL-1 beta and IL-12p70). Acts via both the NF-kappa-B and MAPK signaling pathways. Induces Th1-polarized immune responses (PubMed:22415304).<ref>PMID:20975714</ref> <ref>PMID:22415304</ref>
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== References ==
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==About this Structure==
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<references/>
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[[3oxh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OXH OCA].
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__TOC__
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[[Category: Mycobacterium tuberculosis]]
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</StructureSection>
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[[Category: Alber, T.]]
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[[Category: Large Structures]]
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[[Category: Echols, N.]]
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[[Category: Flynn, E M.]]
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[[Category: Ng, H L.]]
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[[Category: Stephenson, S.]]
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[[Category: TBSGC, TB Structural Genomics Consortium.]]
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[[Category: Antibiotic resistance]]
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[[Category: Babbb fold]]
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[[Category: Hydrolase inhibitor]]
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[[Category: Kinase regulation]]
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[[Category: Mycobacterium tuberculosis]]
[[Category: Mycobacterium tuberculosis]]
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[[Category: Protein structure initiative]]
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[[Category: Alber T]]
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[[Category: Psi]]
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[[Category: Echols N]]
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[[Category: Structural genomic]]
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[[Category: Flynn EM]]
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[[Category: Tb structural genomics consortium]]
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[[Category: Ng H-L]]
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[[Category: Tbsgc]]
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[[Category: Stephenson S]]

Current revision

Mycobacterium tuberculosis kinase inhibitor homolog RV0577

PDB ID 3oxh

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