3p5j
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3p5j is ON HOLD Authors: Bubeck, D., Graham, S.C., Jones, E.Y. Description: The structure of the human RNase H2 complex defines key interaction int...) |
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| - | '''Unreleased structure''' | ||
| - | The | + | ==The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease== |
| + | <StructureSection load='3p5j' size='340' side='right'caption='[[3p5j]], [[Resolution|resolution]] 2.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3p5j]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P5J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P5J FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p5j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p5j OCA], [https://pdbe.org/3p5j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p5j RCSB], [https://www.ebi.ac.uk/pdbsum/3p5j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p5j ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/RNH2A_MOUSE RNH2A_MOUSE] Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.<ref>PMID:19923215</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Ribonuclease 3D structures|Ribonuclease 3D structures]] | |
| - | + | == References == | |
| - | + | <references/> | |
| - | + | __TOC__ | |
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Bubeck D]] | ||
| + | [[Category: Graham SC]] | ||
| + | [[Category: Jones EY]] | ||
Current revision
The structure of the human RNase H2 complex defines key interaction interfaces relevant to enzyme function and human disease
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