3qik
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3qik is ON HOLD Authors: Shen, L., Tong, Y., Tempel, W., Li, Y., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Weigelt, J., Park, H., Structural Gen...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the first PDZ domain of PREX1== | |
| - | + | <StructureSection load='3qik' size='340' side='right'caption='[[3qik]], [[Resolution|resolution]] 2.29Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3qik]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QIK FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.285Å</td></tr> | |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qik OCA], [https://pdbe.org/3qik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qik RCSB], [https://www.ebi.ac.uk/pdbsum/3qik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qik ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PREX1_HUMAN PREX1_HUMAN] Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Arrowsmith CH]] | ||
| + | [[Category: Bountra C]] | ||
| + | [[Category: Edwards AM]] | ||
| + | [[Category: Li Y]] | ||
| + | [[Category: Park H]] | ||
| + | [[Category: Shen L]] | ||
| + | [[Category: Tempel W]] | ||
| + | [[Category: Tong Y]] | ||
| + | [[Category: Weigelt J]] | ||
Current revision
Crystal structure of the first PDZ domain of PREX1
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Categories: Homo sapiens | Large Structures | Arrowsmith CH | Bountra C | Edwards AM | Li Y | Park H | Shen L | Tempel W | Tong Y | Weigelt J
