7tul

<StructureSection load='7tul' size='340' side='right'caption='[[7tul]], [[Resolution|resolution]] 6.50&Aring;' scene=''>

<table><tr><td colspan='2'>[[7tul]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Woodchuck_hepatitis_virus Woodchuck hepatitis virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TUL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TUL FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.5&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tul FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tul OCA], [https://pdbe.org/7tul PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tul RCSB], [https://www.ebi.ac.uk/pdbsum/7tul PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tul ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/HBSAG_WHV5 HBSAG_WHV5] The large envelope protein exists in two topological conformations, one which is termed 'external' or Le-HBsAg and the other 'internal' or Li-HBsAg. In its external conformation the protein attaches the virus to cell receptors and thereby initiating infection. This interaction determines the species specificity and liver tropism. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. The large envelope protein also assures fusion between virion membrane and endosomal membrane. In its internal conformation the protein plays a role in virion morphogenesis and mediates the contact with the nucleocapsid like a matrix protein.[HAMAP-Rule:MF_04075] The middle envelope protein plays an important role in the budding of the virion. It is involved in the induction of budding in a nucleocapsid independent way. In this process the majority of envelope proteins bud to form subviral lipoprotein particles of 22 nm of diameter that do not contain a nucleocapsid.[HAMAP-Rule:MF_04075]

[[Category: Woodchuck hepatitis virus]]