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8oi1
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Yeast 20S proteasome in complex with a photoswitchable cepafungin derivative (transCep4)== | |
| - | + | <StructureSection load='8oi1' size='340' side='right'caption='[[8oi1]], [[Resolution|resolution]] 2.95Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8oi1]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8OI1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8OI1 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.95Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VOX:~{N}-[(2~{S},3~{R})-1-[[(5~{S},8~{S},10~{S})-5-methyl-10-oxidanyl-2,7-bis(oxidanylidene)-1,6-diazacyclododec-8-yl]amino]-3-oxidanyl-1-oxidanylidene-butan-2-yl]-7-[4-[2-(4-methylphenyl)hydrazinyl]phenyl]heptanamide'>VOX</scene></td></tr> |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8oi1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8oi1 OCA], [https://pdbe.org/8oi1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8oi1 RCSB], [https://www.ebi.ac.uk/pdbsum/8oi1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8oi1 ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/PSA2_YEAST PSA2_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Saccharomyces cerevisiae]] |
| - | [[Category: Schuster | + | [[Category: Adibekian A]] |
| + | [[Category: Amatuni A]] | ||
| + | [[Category: Groll M]] | ||
| + | [[Category: Ko T]] | ||
| + | [[Category: Kuttenlochner W]] | ||
| + | [[Category: Morstein J]] | ||
| + | [[Category: Renata H]] | ||
| + | [[Category: Schuster A]] | ||
| + | [[Category: Trauner DH]] | ||
Current revision
Yeast 20S proteasome in complex with a photoswitchable cepafungin derivative (transCep4)
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