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3odt
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3odt is ON HOLD Authors: Pashkova, N., Gakhar, L., Winistorfer, S.C., Yu, L., Ramaswamy, S., Piper, R.C. Description: Crystal structure of WD40 bet...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of WD40 beta propeller domain of Doa1== | |
| - | + | <StructureSection load='3odt' size='340' side='right'caption='[[3odt]], [[Resolution|resolution]] 1.35Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3odt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODT FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.35Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | '' | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3odt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odt OCA], [https://pdbe.org/3odt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3odt RCSB], [https://www.ebi.ac.uk/pdbsum/3odt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3odt ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DOA1_YEAST DOA1_YEAST] Participates in the regulation of the ubiquitin conjugation pathway involving CDC48 by hindering multiubiquitination of substrates at the CDC48 chaperone. May act by preventing the interaction between CDC48 and the E4 enzyme UFD2, leading to prevent multiubiquitination of substrates and subsequent degradation. Essential for maintaining cellular ubiquitin levels.<ref>PMID:15096053</ref> <ref>PMID:8890162</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Saccharomyces cerevisiae]] | ||
| + | [[Category: Gakhar L]] | ||
| + | [[Category: Pashkova N]] | ||
| + | [[Category: Piper RC]] | ||
| + | [[Category: Ramaswamy S]] | ||
| + | [[Category: Winistorfer SC]] | ||
| + | [[Category: Yu L]] | ||
Current revision
Crystal structure of WD40 beta propeller domain of Doa1
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