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3oep

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==Crystal structure of TTHA0988 in space group P43212==
==Crystal structure of TTHA0988 in space group P43212==
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<StructureSection load='3oep' size='340' side='right' caption='[[3oep]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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<StructureSection load='3oep' size='340' side='right'caption='[[3oep]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3oep]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OEP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OEP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3oep]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OEP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OEP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TTHA0988 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 Thermus thermophilus])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oep OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oep RCSB], [http://www.ebi.ac.uk/pdbsum/3oep PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oep FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oep OCA], [https://pdbe.org/3oep PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oep RCSB], [https://www.ebi.ac.uk/pdbsum/3oep PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oep ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q5SJM0_THET8 Q5SJM0_THET8]
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The Thermus thermophilus protein TTHA0988 is a protein of unknown function which represents a fusion of two proteins found almost ubiquitously across the bacterial kingdom. These two proteins perform a role regulating sporulation in Bacillus subtilis, where they are known as KipI and KipA. kipI and kipA genes are usually found immediately adjacent to each other and are often fused to produce a single polypeptide, as is the case with TTHA0988. Here, three crystal forms are reported of TTHA0988, the first structure to be solved from the family of `KipI-KipA fusion' proteins. Comparison of the three forms reveals structural flexibility which can be described as a hinge motion between the `KipI' and `KipA' components. TTHA0988 is annotated in various databases as a putative allophanate hydrolase. However, no such activity could be identified and genetic analysis across species with known allophanate hydrolases indicates that a misannotation has occurred.
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The structure of TTHA0988 from Thermus thermophilus, a KipI-KipA homologue incorrectly annotated as an allophanate hydrolase.,Jacques DA, Langley DB, Kuramitsu S, Yokoyama S, Trewhella J, Guss JM Acta Crystallogr D Biol Crystallogr. 2011 Feb;67(Pt 2):105-11. Epub 2011, Jan 8. PMID:21245531<ref>PMID:21245531</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Thermus thermophilus]]
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[[Category: Large Structures]]
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[[Category: Guss, J M]]
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[[Category: Thermus thermophilus HB8]]
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[[Category: Jacques, D A]]
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[[Category: Guss JM]]
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[[Category: Langley, D B]]
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[[Category: Jacques DA]]
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[[Category: Trewhella, J]]
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[[Category: Langley DB]]
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[[Category: Allophanate hydrolase]]
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[[Category: Trewhella J]]
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[[Category: Cyclophilin]]
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[[Category: Kipa]]
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[[Category: Kipi]]
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[[Category: National project on protein structural and functional analyse]]
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[[Category: Nppsfa]]
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[[Category: Structural genomic]]
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[[Category: Rsgi]]
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[[Category: Unknown function]]
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Current revision

Crystal structure of TTHA0988 in space group P43212

PDB ID 3oep

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