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3oj8
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3oj8 is ON HOLD Authors: Mileni, M, Stevens, R.C., Boger, D.L. Description: alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containi...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain== | |
| + | <StructureSection load='3oj8' size='340' side='right'caption='[[3oj8]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3oj8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OJ8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OJ8:(S)-[(2S)-6-PHENOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL](5-PYRIDIN-2-YL-1,3-OXAZOL-2-YL)METHANOL'>OJ8</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oj8 OCA], [https://pdbe.org/3oj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oj8 RCSB], [https://www.ebi.ac.uk/pdbsum/3oj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oj8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Fatty acid amide hydrolase|Fatty acid amide hydrolase]] | |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
| - | + | [[Category: Large Structures]] | |
| + | [[Category: Rattus norvegicus]] | ||
| + | [[Category: Boger DL]] | ||
| + | [[Category: Mileni M]] | ||
| + | [[Category: Stevens RC]] | ||
Current revision
Alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain
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