This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


3oj8

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (11:16, 21 February 2024) (edit) (undo)
 
(6 intermediate revisions not shown.)
Line 1: Line 1:
-
[[Image:3oj8.jpg|left|200px]]
 
-
<!--
+
==Alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain==
-
The line below this paragraph, containing "STRUCTURE_3oj8", creates the "Structure Box" on the page.
+
<StructureSection load='3oj8' size='340' side='right'caption='[[3oj8]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-
You may change the PDB parameter (which sets the PDB file loaded into the applet)
+
== Structural highlights ==
-
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+
<table><tr><td colspan='2'>[[3oj8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OJ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OJ8 FirstGlance]. <br>
-
or leave the SCENE parameter empty for the default display.
+
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-
-->
+
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=OJ8:(S)-[(2S)-6-PHENOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-2-YL](5-PYRIDIN-2-YL-1,3-OXAZOL-2-YL)METHANOL'>OJ8</scene></td></tr>
-
{{STRUCTURE_3oj8| PDB=3oj8 | SCENE= }}
+
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oj8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oj8 OCA], [https://pdbe.org/3oj8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oj8 RCSB], [https://www.ebi.ac.uk/pdbsum/3oj8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oj8 ProSAT]</span></td></tr>
 +
</table>
 +
== Function ==
 +
[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity).
-
===Alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain===
+
==See Also==
-
 
+
*[[Fatty acid amide hydrolase|Fatty acid amide hydrolase]]
-
 
+
__TOC__
-
<!--
+
</StructureSection>
-
The line below this paragraph, {{ABSTRACT_PUBMED_21428410}}, adds the Publication Abstract to the page
+
[[Category: Large Structures]]
-
(as it appears on PubMed at http://www.pubmed.gov), where 21428410 is the PubMed ID number.
+
-
-->
+
-
{{ABSTRACT_PUBMED_21428410}}
+
-
 
+
-
==About this Structure==
+
-
[[3oj8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OJ8 OCA].
+
-
 
+
-
==Reference==
+
-
<ref group="xtra">PMID:021428410</ref><references group="xtra"/>
+
-
[[Category: Fatty acid amide hydrolase]]
+
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
-
[[Category: Boger, D L.]]
+
[[Category: Boger DL]]
-
[[Category: Mileni, M.]]
+
[[Category: Mileni M]]
-
[[Category: Stevens, R C.]]
+
[[Category: Stevens RC]]
-
[[Category: Enantiomer]]
+
-
[[Category: Faah]]
+
-
[[Category: Hydrolase-hydrolase inhibitor complex]]
+
-
[[Category: Membrane]]
+
-
[[Category: Oxazole]]
+
-
[[Category: Protein-inhibitor complex]]
+
-
[[Category: Serine hydrolase]]
+

Current revision

Alpha-Ketoheterocycle Inhibitors of Fatty Acid Amide Hydrolase Containing Additional Conformational Contraints in the Acyl Side Chain

PDB ID 3oj8

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/3oj8"
Personal tools