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3ont
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| - | {{STRUCTURE_3ont| PDB=3ont | SCENE= }} | ||
| - | ===The Crystal Structure of Spot14, a modulator of lipogenesis=== | ||
| - | {{ABSTRACT_PUBMED_20952656}} | ||
| - | == | + | ==The Crystal Structure of Spot14, a modulator of lipogenesis== |
| - | [[http://www.uniprot.org/uniprot/THRSP_MOUSE THRSP_MOUSE | + | <StructureSection load='3ont' size='340' side='right'caption='[[3ont]], [[Resolution|resolution]] 2.65Å' scene=''> |
| - | + | == Structural highlights == | |
| - | == | + | <table><tr><td colspan='2'>[[3ont]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ONT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ONT FirstGlance]. <br> |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ont FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ont OCA], [https://pdbe.org/3ont PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ont RCSB], [https://www.ebi.ac.uk/pdbsum/3ont PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ont ProSAT]</span></td></tr> | |
| - | + | </table> | |
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/THRSP_MOUSE THRSP_MOUSE] Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA. May function as transcriptional coactivator. May modulate the transcription factor activity of THRB (By similarity).<ref>PMID:15890771</ref> <ref>PMID:20952656</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
| - | [[Category: Colbert | + | [[Category: Colbert CL]] |
| - | [[Category: Deisenhofer | + | [[Category: Deisenhofer J]] |
| - | [[Category: Kwon | + | [[Category: Kwon HJ]] |
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Current revision
The Crystal Structure of Spot14, a modulator of lipogenesis
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