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3ou0

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[[Image:3ou0.png|left|200px]]
 
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==re-refined 3CS0==
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The line below this paragraph, containing "STRUCTURE_3ou0", creates the "Structure Box" on the page.
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<StructureSection load='3ou0' size='340' side='right'caption='[[3ou0]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ou0]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OU0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OU0 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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{{STRUCTURE_3ou0| PDB=3ou0 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ou0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ou0 OCA], [https://pdbe.org/3ou0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ou0 RCSB], [https://www.ebi.ac.uk/pdbsum/3ou0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ou0 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/DEGP_ECOLI DEGP_ECOLI] DegP acts as a chaperone at low temperatures but switches to a peptidase (heat shock protein) at higher temperatures. It degrades transiently denatured and unfolded proteins which accumulate in the periplasm following heat shock or other stress conditions. DegP is efficient with Val-Xaa and Ile-Xaa peptide bonds, suggesting a preference for beta-branched side chain amino acids. Only unfolded proteins devoid of disulfide bonds appear capable of being cleaved, thereby preventing non-specific proteolysis of folded proteins. Its proteolytic activity is essential for the survival of cells at elevated temperatures. It can degrade IciA, ada, casein, globin and PapA. DegP shares specificity with DegQ. DegP is also involved in the biogenesis of partially folded outer-membrane proteins (OMP).<ref>PMID:2180903</ref> <ref>PMID:8830688</ref> <ref>PMID:10319814</ref> <ref>PMID:18505836</ref> <ref>PMID:12730160</ref> <ref>PMID:18496527</ref>
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===re-refined 3CS0===
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==See Also==
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_18496527}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 18496527 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_18496527}}
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==About this Structure==
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[[3ou0]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ ] and [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OU0 OCA].
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==Reference==
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<ref group="xtra">PMID:018496527</ref><ref group="xtra">PMID:021458668</ref><references group="xtra"/>
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[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
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[[Category: Grant, R A.]]
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[[Category: Large Structures]]
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[[Category: Kim, S.]]
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[[Category: Grant RA]]
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[[Category: Sauer, R T.]]
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[[Category: Kim S]]
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[[Category: Hydrolase]]
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[[Category: Sauer RT]]
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[[Category: Protease]]
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Current revision

re-refined 3CS0

PDB ID 3ou0

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