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3ov6

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[[Image:3ov6.jpg|left|200px]]
 
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==CD1c in complex with MPM (mannosyl-beta1-phosphomycoketide)==
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The line below this paragraph, containing "STRUCTURE_3ov6", creates the "Structure Box" on the page.
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<StructureSection load='3ov6' size='340' side='right'caption='[[3ov6]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ov6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OV6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OV6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.502&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D12:DODECANE'>D12</scene>, <scene name='pdbligand=MK0:1-O-[(S)-HYDROXY{[(4S,8S,16S,20S)-4,8,12,16,20-PENTAMETHYLHEPTACOSYL]OXY}PHOSPHORYL]-BETA-D-MANNOPYRANOSE'>MK0</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
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{{STRUCTURE_3ov6| PDB=3ov6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ov6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ov6 OCA], [https://pdbe.org/3ov6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ov6 RCSB], [https://www.ebi.ac.uk/pdbsum/3ov6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ov6 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:[https://omim.org/entry/241600 241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.<ref>PMID:16549777</ref> Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.<ref>PMID:3532124</ref> <ref>PMID:1336137</ref> <ref>PMID:7554280</ref> <ref>PMID:4586824</ref> <ref>PMID:8084451</ref> <ref>PMID:12119416</ref> <ref>PMID:12796775</ref> <ref>PMID:16901902</ref> <ref>PMID:16491088</ref> <ref>PMID:17646174</ref> <ref>PMID:18835253</ref> <ref>PMID:18395224</ref> <ref>PMID:19284997</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/CD1C_HUMAN CD1C_HUMAN] Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:10786796</ref> <ref>PMID:10890914</ref> <ref>PMID:10899914</ref> <ref>PMID:21167756</ref> [https://www.uniprot.org/uniprot/CD1B_HUMAN CD1B_HUMAN] Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.<ref>PMID:10981968</ref> <ref>PMID:14716313</ref> [https://www.uniprot.org/uniprot/B2MG_HUMAN B2MG_HUMAN] Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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===CD1c in complex with MPM (mannosyl-beta1-phosphomycoketide)===
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==See Also==
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*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
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*[[CD1|CD1]]
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== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_21167756}}, adds the Publication Abstract to the page
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 21167756 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_21167756}}
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==About this Structure==
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[[3ov6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OV6 OCA].
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==Reference==
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<ref group="xtra">PMID:21167756</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Adams, E J.]]
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[[Category: Large Structures]]
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[[Category: Faraldo-Gomez, J D.]]
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[[Category: Adams EJ]]
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[[Category: Garzon, D.]]
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[[Category: Faraldo-Gomez JD]]
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[[Category: Haddadian, E J.]]
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[[Category: Garzon D]]
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[[Category: Hawk, A J.]]
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[[Category: Haddadian EJ]]
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[[Category: Kazen, A R.]]
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[[Category: Hawk AJ]]
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[[Category: Li, N S.]]
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[[Category: Kazen AR]]
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[[Category: Meredith, S C.]]
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[[Category: Li NS]]
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[[Category: Piccirilli, J A.]]
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[[Category: Meredith SC]]
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[[Category: Saghatelian, A.]]
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[[Category: Piccirilli JA]]
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[[Category: Scharf, L.]]
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[[Category: Saghatelian A]]
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[[Category: Shah, S.]]
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[[Category: Scharf L]]
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[[Category: Zhang, T.]]
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[[Category: Shah S]]
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[[Category: Zhang T]]

Current revision

CD1c in complex with MPM (mannosyl-beta1-phosphomycoketide)

PDB ID 3ov6

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