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3ovx

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[[Image:3ovx.png|left|200px]]
 
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{{STRUCTURE_3ovx| PDB=3ovx | SCENE= }}
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==Cathepsin S in complex with a covalent inhibitor with an aldehyde warhead==
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<StructureSection load='3ovx' size='340' side='right'caption='[[3ovx]], [[Resolution|resolution]] 1.49&Aring;' scene=''>
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===Cathepsin S in complex with a covalent inhibitor with an aldehyde warhead===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ovx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OVX FirstGlance]. <br>
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{{ABSTRACT_PUBMED_21030256}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.49&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=O64:2-CHLORO-N-[(1S)-1-FORMYLPROPYL]-3-(TRIFLUOROMETHYL)BENZAMIDE'>O64</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ovx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ovx OCA], [https://pdbe.org/3ovx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ovx RCSB], [https://www.ebi.ac.uk/pdbsum/3ovx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ovx ProSAT]</span></td></tr>
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[[3ovx]] is a 2 chain structure of [[Cathepsin]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OVX OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CATS_HUMAN CATS_HUMAN] Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond-specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N.
==See Also==
==See Also==
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*[[Cathepsin|Cathepsin]]
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*[[Cathepsin 3D structures|Cathepsin 3D structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:021030256</ref><references group="xtra"/>
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[[Category: Cathepsin S]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Fradera, X.]]
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[[Category: Large Structures]]
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[[Category: Uitdehaag, J C.M.]]
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[[Category: Fradera X]]
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[[Category: Zeeland, M van.]]
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[[Category: Uitdehaag JCM]]
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[[Category: Aldehyde warhead]]
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[[Category: Van Zeeland M]]
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[[Category: Cathepsin s]]
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[[Category: Covalent inhibitor]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Ligand is covalently bound to cys25]]
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[[Category: Lysosomeal protein]]
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Current revision

Cathepsin S in complex with a covalent inhibitor with an aldehyde warhead

PDB ID 3ovx

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