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3oza

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==Crystal Structure of Plasmodium falciparum 3-Phosphoglycerate Kinase==
==Crystal Structure of Plasmodium falciparum 3-Phosphoglycerate Kinase==
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<StructureSection load='3oza' size='340' side='right' caption='[[3oza]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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<StructureSection load='3oza' size='340' side='right'caption='[[3oza]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3oza]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum Plasmodium falciparum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OZA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3OZA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3oza]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OZA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OZA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ltk|1ltk]], [[3oz7|3oz7]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oza OCA], [https://pdbe.org/3oza PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oza RCSB], [https://www.ebi.ac.uk/pdbsum/3oza PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oza ProSAT]</span></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PGK, PFI1105w ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=5833 Plasmodium falciparum])</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoglycerate_kinase Phosphoglycerate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.2.3 2.7.2.3] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3oza FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oza OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3oza RCSB], [http://www.ebi.ac.uk/pdbsum/3oza PDBsum]</span></td></tr>
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</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/PGK_PLAF7 PGK_PLAF7]
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3-Phosphoglycerate kinase (EC 2.7.2.3) is a key enzyme in the glycolytic pathway and catalyzes an important phosphorylation step leading to the production of ATP. The crystal structure of Plasmodium falciparum phosphoglycerate kinase (PfPGK) in the open conformation is presented in two different crystal forms, namely I222 and P6(1)22. I222 is solved using MAD and refined at 3A whereas P6(1)22A is solved using MR and refined at 2.7A. I222 has three monomers in asymmetric unit whereas P6(1)22 has two monomers in the asymmetric unit. Sulphate ion is located at the active site where ATP binds in both crystal forms, but no Mg(2+) ion is observed. For the first time another sulphate ion is found at the basic patch where the 3-phosphate of 1,3-biphosphoglycerate normally binds. This was found in both chains of P6(1)22 but only in A-chain of I222 crystal form.
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Crystal structure of Plasmodium falciparum phosphoglycerate kinase: Evidence for anion binding in the basic patch.,Smith CD, Chattopadhyay D, Pal B Biochem Biophys Res Commun. 2011 Jul 25. PMID:21798238<ref>PMID:21798238</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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==See Also==
==See Also==
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*[[Phosphoglycerate Kinase|Phosphoglycerate Kinase]]
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*[[Phosphoglycerate kinase 3D structures|Phosphoglycerate kinase 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Phosphoglycerate kinase]]
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[[Category: Large Structures]]
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[[Category: Plasmodium falciparum]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Chattopadhyay, D]]
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[[Category: Chattopadhyay D]]
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[[Category: Pal, B]]
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[[Category: Pal B]]
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[[Category: Smith, C D]]
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[[Category: Smith CD]]
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[[Category: Atp binding]]
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[[Category: Glycolysis]]
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[[Category: Kinase]]
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[[Category: Malaraia parasite]]
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[[Category: Nucleotide binding]]
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[[Category: Transferase]]
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Current revision

Crystal Structure of Plasmodium falciparum 3-Phosphoglycerate Kinase

PDB ID 3oza

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