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3ozs

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[[Image:3ozs.png|left|200px]]
 
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==Rat catechol O-methyltransferase in complex with a catechol-type, trifluoromethyl-imidazolyl-containing inhibitor - humanized form==
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The line below this paragraph, containing "STRUCTURE_3ozs", creates the "Structure Box" on the page.
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<StructureSection load='3ozs' size='340' side='right'caption='[[3ozs]], [[Resolution|resolution]] 1.44&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3ozs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OZS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OZS FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.44&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OZS:N-[(E)-3-[(2R,3S,4R,5R)-3,4-DIHYDROXY-5-[4-(TRIFLUOROMETHYL)IMIDAZOL-1-YL]OXOLAN-2-YL]PROP-2-ENYL]-2,3-DIHYDROXY-5-NITRO-BENZAMIDE'>OZS</scene></td></tr>
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{{STRUCTURE_3ozs| PDB=3ozs | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ozs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ozs OCA], [https://pdbe.org/3ozs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ozs RCSB], [https://www.ebi.ac.uk/pdbsum/3ozs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ozs ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/COMT_RAT COMT_RAT] Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
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===Rat Catechol O-Methyltransferase in complex with a bisubstrate inhibitor - humanized form===
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==See Also==
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*[[Catechol O-methyltransferase 3D structures|Catechol O-methyltransferase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3ozs]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OZS OCA].
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[[Category: Large Structures]]
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==Reference==
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<ref group="xtra">PMID:021538606</ref><references group="xtra"/>
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[[Category: Catechol O-methyltransferase]]
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[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Rudolph, M G.]]
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[[Category: Benz J]]
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[[Category: Ehler A]]
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[[Category: Rudolph MG]]
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[[Category: Schlatter D]]
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[[Category: Stihle M]]

Current revision

Rat catechol O-methyltransferase in complex with a catechol-type, trifluoromethyl-imidazolyl-containing inhibitor - humanized form

PDB ID 3ozs

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