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3p3i

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[[Image:3p3i.png|left|200px]]
 
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{{STRUCTURE_3p3i| PDB=3p3i | SCENE= }}
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==Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate and CoA==
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<StructureSection load='3p3i' size='340' side='right'caption='[[3p3i]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate and CoA===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3p3i]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P3I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P3I FirstGlance]. <br>
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{{ABSTRACT_PUBMED_20836570}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=COA:COENZYME+A'>COA</scene>, <scene name='pdbligand=FAH:FLUOROACETIC+ACID'>FAH</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p3i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p3i OCA], [https://pdbe.org/3p3i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p3i RCSB], [https://www.ebi.ac.uk/pdbsum/3p3i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p3i ProSAT]</span></td></tr>
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[[3p3i]] is a 6 chain structure of [[Thioesterase]] with sequence from [http://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P3I OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/FLK_STRCT FLK_STRCT] Hydrolyzes fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance. Can not use acetyl-CoA as substrate.<ref>PMID:16720268</ref> <ref>PMID:20836570</ref>
==See Also==
==See Also==
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*[[Thioesterase|Thioesterase]]
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
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== References ==
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==Reference==
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<references/>
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<ref group="xtra">PMID:020836570</ref><references group="xtra"/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Streptomyces cattleya]]
[[Category: Streptomyces cattleya]]
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[[Category: Chang, M C.Y.]]
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[[Category: Chang MCY]]
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[[Category: Coyle, S M.]]
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[[Category: Coyle SM]]
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[[Category: Doudna, J A.]]
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[[Category: Doudna JA]]
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[[Category: Jinek, M.]]
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[[Category: Jinek M]]
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[[Category: Weeks, A M.]]
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[[Category: Weeks AM]]
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[[Category: Hot dog-fold]]
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[[Category: Hydrolase]]
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[[Category: Thioesterase]]
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Current revision

Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate and CoA

PDB ID 3p3i

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