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3p4u

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[[Image:3p4u.jpg|left|200px]]
 
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==Crystal structure of active caspase-6 in complex with Ac-VEID-CHO inhibitor==
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The line below this paragraph, containing "STRUCTURE_3p4u", creates the "Structure Box" on the page.
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<StructureSection load='3p4u' size='340' side='right'caption='[[3p4u]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3p4u]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P4U FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=ASJ:(3S)-3-AMINO-4-HYDROXYBUTANOIC+ACID'>ASJ</scene>, <scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene></td></tr>
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{{STRUCTURE_3p4u| PDB=3p4u | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p4u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p4u OCA], [https://pdbe.org/3p4u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p4u RCSB], [https://www.ebi.ac.uk/pdbsum/3p4u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p4u ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/CASP6_HUMAN CASP6_HUMAN] Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
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===Crystal structure of active caspase-6 in complex with Ac-VEID-CHO inhibitor===
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==See Also==
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*[[Caspase 3D structures|Caspase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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[[3p4u]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P4U OCA].
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[[Category: Caspase-6]]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Dominguez, C.]]
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[[Category: Large Structures]]
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[[Category: Kiselyov, A.]]
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[[Category: Dominguez C]]
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[[Category: Lamers, M B.A C.]]
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[[Category: Kiselyov A]]
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[[Category: Maillard, M.]]
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[[Category: Lamers MBAC]]
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[[Category: Mueller, I.]]
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[[Category: Maillard M]]
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[[Category: Munoz, I.]]
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[[Category: Mueller I]]
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[[Category: Ritchie, A J.]]
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[[Category: Munoz I]]
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[[Category: Caspase]]
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[[Category: Ritchie AJ]]
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[[Category: Competitive inhibition]]
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[[Category: Huntington's disease]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Protease]]
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Current revision

Crystal structure of active caspase-6 in complex with Ac-VEID-CHO inhibitor

PDB ID 3p4u

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