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3p8d

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[[Image:3p8d.png|left|200px]]
 
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{{STRUCTURE_3p8d| PDB=3p8d | SCENE= }}
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==Crystal structure of the second Tudor domain of human PHF20 (homodimer form)==
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<StructureSection load='3p8d' size='340' side='right'caption='[[3p8d]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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===Crystal structure of the second Tudor domain of human PHF20 (homodimer form)===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3p8d]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P8D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P8D FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22864287}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p8d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p8d OCA], [https://pdbe.org/3p8d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p8d RCSB], [https://www.ebi.ac.uk/pdbsum/3p8d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p8d ProSAT]</span></td></tr>
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==About this Structure==
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</table>
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[[3p8d]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P8D OCA].
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== Function ==
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[https://www.uniprot.org/uniprot/PHF20_HUMAN PHF20_HUMAN] Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage.<ref>PMID:20018852</ref> <ref>PMID:22864287</ref>
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==Reference==
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== References ==
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<ref group="xtra">PMID:022864287</ref><references group="xtra"/>
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Botuyan, M V.]]
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[[Category: Large Structures]]
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[[Category: Cui, G.]]
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[[Category: Botuyan MV]]
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[[Category: Lee, J.]]
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[[Category: Cui G]]
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[[Category: Mer, G.]]
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[[Category: Lee J]]
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[[Category: Thompson, J R.]]
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[[Category: Mer G]]
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[[Category: Histone binding]]
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[[Category: Thompson JR]]
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[[Category: Lysine-methylated p53 binding]]
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[[Category: Protein binding]]
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[[Category: Tudor domain]]
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Current revision

Crystal structure of the second Tudor domain of human PHF20 (homodimer form)

PDB ID 3p8d

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