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3p8f

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[[Image:3p8f.jpg|left|200px]]
 
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==Crystal Structure of MT-SP1 in complex with SFTI-1==
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The line below this paragraph, containing "STRUCTURE_3p8f", creates the "Structure Box" on the page.
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<StructureSection load='3p8f' size='340' side='right'caption='[[3p8f]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3p8f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helianthus_annuus Helianthus annuus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P8F FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr>
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{{STRUCTURE_3p8f| PDB=3p8f | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p8f OCA], [https://pdbe.org/3p8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p8f RCSB], [https://www.ebi.ac.uk/pdbsum/3p8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p8f ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[https://omim.org/entry/610765 610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.
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===Crystal Structure of MT-SP1 in complex with SFTI-1===
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==See Also==
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*[[Matriptase 3D structures|Matriptase 3D structures]]
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*[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]]
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== References ==
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<references/>
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(as it appears on PubMed at http://www.pubmed.gov), where 21693064 is the PubMed ID number.
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__TOC__
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</StructureSection>
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{{ABSTRACT_PUBMED_21693064}}
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[[Category: Helianthus annuus]]
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==About this Structure==
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[[3p8f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P8F OCA].
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==Reference==
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<ref group="xtra">PMID:021693064</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Matriptase]]
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[[Category: Large Structures]]
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[[Category: Chen, L.]]
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[[Category: Chen L]]
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[[Category: Huang, M.]]
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[[Category: Huang M]]
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[[Category: Yuan, C.]]
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[[Category: Yuan C]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Protein-inhibitor complex]]
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Current revision

Crystal Structure of MT-SP1 in complex with SFTI-1

PDB ID 3p8f

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