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3p8f
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| - | {{STRUCTURE_3p8f| PDB=3p8f | SCENE= }} | ||
| - | ===Crystal Structure of MT-SP1 in complex with SFTI-1=== | ||
| - | {{ABSTRACT_PUBMED_21693064}} | ||
| - | == | + | ==Crystal Structure of MT-SP1 in complex with SFTI-1== |
| - | [[http:// | + | <StructureSection load='3p8f' size='340' side='right'caption='[[3p8f]], [[Resolution|resolution]] 2.00Å' scene=''> |
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3p8f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helianthus_annuus Helianthus annuus] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P8F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P8F FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p8f OCA], [https://pdbe.org/3p8f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p8f RCSB], [https://www.ebi.ac.uk/pdbsum/3p8f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p8f ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[https://omim.org/entry/610765 610765]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. | ||
| - | == | + | ==See Also== |
| - | [[ | + | *[[Matriptase 3D structures|Matriptase 3D structures]] |
| - | + | *[[Trypsin inhibitor 3D structures|Trypsin inhibitor 3D structures]] | |
| - | == | + | == References == |
| - | + | <references/> | |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Helianthus annuus]] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: Chen | + | [[Category: Chen L]] |
| - | [[Category: Huang | + | [[Category: Huang M]] |
| - | [[Category: Yuan | + | [[Category: Yuan C]] |
| - | + | ||
| - | + | ||
Current revision
Crystal Structure of MT-SP1 in complex with SFTI-1
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