Ubiquitin-fold modifier
From Proteopedia
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<StructureSection load='5iaa' size='340' side='right' caption='Human ubiquitin-fold modifier (pink, yellow) complex with ubiquitin-like modifier activating enzyme (green, cyan) (PDB code [[5iaa]]' scene='87/873802/Cv/1' > | <StructureSection load='5iaa' size='340' side='right' caption='Human ubiquitin-fold modifier (pink, yellow) complex with ubiquitin-like modifier activating enzyme (green, cyan) (PDB code [[5iaa]]' scene='87/873802/Cv/1' > | ||
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== Function == | == Function == | ||
'''Ubiquitin-fold modifier''' (Ufm1) is a member of the ubiquitin-like family. Ufm1 is covalently attached to Lys residues of substrate proteins<ref>PMID:21494687</ref>. This attachment is called Ufmylation and requires '''Ubiquitin-like modifier activating enzyme''' (UBA5) and '''Ufm1-conjugating enzyme''' (Ufc1). Ufmylation is a type of post-translational modification that deals with fine-tuned and complex cellular activities and is involved in reticulophagy induced by ER stress<ref>PMID:31129212</ref>. Ufmylation is aribosomal modification specialized to facilitate metazoan-specific protein biogenesis at the ER<ref>PMID:30626644</ref>. | '''Ubiquitin-fold modifier''' (Ufm1) is a member of the ubiquitin-like family. Ufm1 is covalently attached to Lys residues of substrate proteins<ref>PMID:21494687</ref>. This attachment is called Ufmylation and requires '''Ubiquitin-like modifier activating enzyme''' (UBA5) and '''Ufm1-conjugating enzyme''' (Ufc1). Ufmylation is a type of post-translational modification that deals with fine-tuned and complex cellular activities and is involved in reticulophagy induced by ER stress<ref>PMID:31129212</ref>. Ufmylation is aribosomal modification specialized to facilitate metazoan-specific protein biogenesis at the ER<ref>PMID:30626644</ref>. | ||
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<scene name='87/873802/Cv/2'>The 3D structure of the complex between Ufm1 and UBA</scene> shows the Ufm1 critical binding sequence and the <scene name='87/873802/Cv/4'>interactions between the 2 modifying enzymes</scene> <ref>PMID:27653677</ref>. | <scene name='87/873802/Cv/2'>The 3D structure of the complex between Ufm1 and UBA</scene> shows the Ufm1 critical binding sequence and the <scene name='87/873802/Cv/4'>interactions between the 2 modifying enzymes</scene> <ref>PMID:27653677</ref>. | ||
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== 3D Structures of Ubiquitin-fold modifier == | == 3D Structures of Ubiquitin-fold modifier == | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
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==References== | ==References== | ||
<references /> | <references /> | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:34, 28 February 2024
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