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8jbf

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(New page: '''Unreleased structure''' The entry 8jbf is ON HOLD Authors: Sun, W.J., Yang, F., Zhang, H.H., Yuan, Q.N., Yin, W.C., Shi, P., Eric, X., Tian, C.L. Description: Substance P bound to a...)
Current revision (09:37, 1 March 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8jbf is ON HOLD
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==Senktide bound to active human neurokinin 3 receptor in complex with Gq==
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<StructureSection load='8jbf' size='340' side='right'caption='[[8jbf]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
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Authors: Sun, W.J., Yang, F., Zhang, H.H., Yuan, Q.N., Yin, W.C., Shi, P., Eric, X., Tian, C.L.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8jbf]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Mus_musculoides Mus musculoides] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JBF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JBF FirstGlance]. <br>
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Description: Substance P bound to active human neurokinin 3 receptor in complex with Gq
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jbf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jbf OCA], [https://pdbe.org/8jbf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jbf RCSB], [https://www.ebi.ac.uk/pdbsum/8jbf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jbf ProSAT]</span></td></tr>
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[[Category: Shi, P]]
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</table>
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[[Category: Tian, C.L]]
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== Disease ==
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[[Category: Yin, W.C]]
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[https://www.uniprot.org/uniprot/NK3R_HUMAN NK3R_HUMAN] Normosmic congenital hypogonadotropic hypogonadism;Kallmann syndrome. The disease is caused by variants affecting distinct genetic loci, including the gene represented in this entry. The genetics of hypogonadotropic hypogonadism involves various modes of transmission. Oligogenic inheritance has been reported in some patients carrying mutations in TACR3 as well as in other HH-associated genes including FGFR1, SPRY4 and KAL1 (PubMed:23643382).<ref>PMID:23643382</ref>
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[[Category: Yuan, Q.N]]
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== Function ==
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[[Category: Yang, F]]
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[https://www.uniprot.org/uniprot/NK3R_HUMAN NK3R_HUMAN] This is a receptor for the tachykinin neuropeptide neuromedin-K (neurokinin B). It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinity of this receptor to tachykinins is: neuromedin-K > substance K > substance P.
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[[Category: Zhang, H.H]]
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== References ==
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[[Category: Sun, W.J]]
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<references/>
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[[Category: Eric, X]]
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__TOC__
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</StructureSection>
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[[Category: Bos taurus]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Mus musculoides]]
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[[Category: Rattus norvegicus]]
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[[Category: Eric X]]
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[[Category: Shi P]]
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[[Category: Sun WJ]]
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[[Category: Tian CL]]
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[[Category: Yang F]]
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[[Category: Yin WC]]
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[[Category: Yuan QN]]
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[[Category: Zhang HH]]

Current revision

Senktide bound to active human neurokinin 3 receptor in complex with Gq

PDB ID 8jbf

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