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8jel
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 8jel is ON HOLD Authors: Jian, J.S., Xiangxiang, X.Z., Jing, J.S. Description: Crystal structure of TIGIT in complexed with Ociperlimab, crystal fo...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I== | |
| - | + | <StructureSection load='8jel' size='340' side='right'caption='[[8jel]], [[Resolution|resolution]] 2.45Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8jel]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JEL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JEL FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jel FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jel OCA], [https://pdbe.org/8jel PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jel RCSB], [https://www.ebi.ac.uk/pdbsum/8jel PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jel ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: | + | == Function == |
| - | [[Category: | + | [https://www.uniprot.org/uniprot/TIGIT_HUMAN TIGIT_HUMAN] Binds with high affinity to the poliovirus receptor (PVR) which causes increased secretion of IL10 and decreased secretion of IL12B and suppresses T-cell activation by promoting the generation of mature immunoregulatory dendritic cells. |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Song J]] | ||
| + | [[Category: Sun J]] | ||
| + | [[Category: Zhang XX]] | ||
Current revision
Crystal structure of TIGIT in complexed with Ociperlimab, crystal form I
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