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3rmu

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'''Unreleased structure'''
 
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The entry 3rmu is ON HOLD
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==Crystal structure of human Methylmalonyl-CoA epimerase, MCEE==
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<StructureSection load='3rmu' size='340' side='right'caption='[[3rmu]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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Authors: Chaikuad, A., Krysztofinska, E., Froese, D.S. , Yue, W.W., Vollmar, M., Muniz, J.R.C., von Delft, F., Weigelt, J. , Arrowsmith, C.H. , Edwards, A.M. , Bountra, C. , Oppermann, O. , Structural Genomics Consortium (SGC)
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3rmu]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RMU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RMU FirstGlance]. <br>
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Description: Crystal structure of human Methylmalonyl-CoA epimerase, MCEE
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CO:COBALT+(II)+ION'>CO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rmu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rmu OCA], [https://pdbe.org/3rmu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rmu RCSB], [https://www.ebi.ac.uk/pdbsum/3rmu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rmu ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/MCEE_HUMAN MCEE_HUMAN] Vitamin B12-unresponsive methylmalonic acidemia. Methylmalonyl-CoA epimerase deficiency (MCEED) [MIM:[https://omim.org/entry/251120 251120]: Autosomal recessive inborn error of amino acid metabolism, involving valine, threonine, isoleucine and methionine. This organic aciduria may present in the neonatal period with life-threatening metabolic acidosis, hyperammonemia, feeding difficulties, pancytopenia and coma. Note=The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:16752391</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/MCEE_HUMAN MCEE_HUMAN]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bountra C]]
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[[Category: Chaikuad A]]
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[[Category: Edwards AM]]
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[[Category: Froese DS]]
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[[Category: Krysztofinska E]]
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[[Category: Muniz JRC]]
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[[Category: Oppermann U]]
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[[Category: Vollmar M]]
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[[Category: Weigelt J]]
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[[Category: Yue WW]]
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[[Category: Von Delft F]]

Current revision

Crystal structure of human Methylmalonyl-CoA epimerase, MCEE

PDB ID 3rmu

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