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3rrk

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==Crystal structure of the cytoplasmic N-terminal domain of subunit I, homolog of subunit a, of V-ATPase==
==Crystal structure of the cytoplasmic N-terminal domain of subunit I, homolog of subunit a, of V-ATPase==
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<StructureSection load='3rrk' size='340' side='right' caption='[[3rrk]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
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<StructureSection load='3rrk' size='340' side='right'caption='[[3rrk]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3rrk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Meird Meird]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RRK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3RRK FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3rrk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Meiothermus_ruber_DSM_1279 Meiothermus ruber DSM 1279]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RRK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RRK FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.64&#8491;</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Mrub_0956 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=504728 MEIRD])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NHE:2-[N-CYCLOHEXYLAMINO]ETHANE+SULFONIC+ACID'>NHE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3rrk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rrk OCA], [http://pdbe.org/3rrk PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3rrk RCSB], [http://www.ebi.ac.uk/pdbsum/3rrk PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3rrk ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rrk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rrk OCA], [https://pdbe.org/3rrk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rrk RCSB], [https://www.ebi.ac.uk/pdbsum/3rrk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rrk ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/D3PQI8_MEIRD D3PQI8_MEIRD]
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Subunit "a" is associated with the membrane-bound (V(0)) complex of eukaryotic vacuolar H(+)-ATPase acidification machinery. It has also been shown recently to be involved in diverse membrane fusion/secretory functions independent of acidification. Here, we report the crystal structure of the N-terminal cytosolic domain from the Meiothermus ruber subunit "I" homolog of subunit a. The structure is composed of a curved long central alpha-helix bundle capped on both ends by two lobes with similar alpha/beta architecture. Based on the structure, a reasonable model of its eukaryotic subunit a counterpart was obtained. The crystal structure and model fit well into reconstruction densities from electron microscopy of prokaryotic and eukaryotic vacuolar H(+)-ATPases, respectively, clarifying their orientations and interactions and revealing features that could enable subunit a to play a role in membrane fusion/secretion.
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Crystal Structure of the Cytoplasmic N-Terminal Domain of Subunit I, a Homolog of Subunit a, of V-ATPase.,Srinivasan S, Vyas NK, Baker ML, Quiocho FA J Mol Biol. 2011 Jul 22. PMID:21787787<ref>PMID:21787787</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3rrk" style="background-color:#fffaf0;"></div>
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==See Also==
==See Also==
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*[[ATPase|ATPase]]
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*[[ATPase 3D structures|ATPase 3D structures]]
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Meird]]
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[[Category: Large Structures]]
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[[Category: Baker, M L]]
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[[Category: Meiothermus ruber DSM 1279]]
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[[Category: Quiocho, F A]]
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[[Category: Baker ML]]
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[[Category: Srinivasan, S]]
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[[Category: Quiocho FA]]
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[[Category: Vyas, N K]]
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[[Category: Srinivasan S]]
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[[Category: Alpha beta fold]]
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[[Category: Vyas NK]]
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[[Category: Proton pump]]
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[[Category: Proton transport]]
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[[Category: Subunit i/a]]
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[[Category: V-atpase]]
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Current revision

Crystal structure of the cytoplasmic N-terminal domain of subunit I, homolog of subunit a, of V-ATPase

PDB ID 3rrk

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