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3sdg
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Ethionamide Boosters Part 2: Combining Bioisosteric Replacement and Structure-Based Drug Design to Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors.== | |
| + | <StructureSection load='3sdg' size='340' side='right'caption='[[3sdg]], [[Resolution|resolution]] 1.87Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[3sdg]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SDG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SDG FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3SE:4,4,4-TRIFLUORO-1-{4-[3-(1,3-THIAZOL-2-YL)-1,2,4-OXADIAZOL-5-YL]PIPERIDIN-1-YL}BUTAN-1-ONE'>3SE</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sdg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sdg OCA], [https://pdbe.org/3sdg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sdg RCSB], [https://www.ebi.ac.uk/pdbsum/3sdg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sdg ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/ETHR_MYCTU ETHR_MYCTU] Involved in the repression of the monooxygenase EthA which is responsible of the formation of the active metabolite of ethionamide (ETH).<ref>PMID:10869356</ref> <ref>PMID:10944230</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Tetracycline repressor protein 3D structures|Tetracycline repressor protein 3D structures]] | |
| - | + | == References == | |
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mycobacterium tuberculosis H37Rv]] | ||
| + | [[Category: Baulard AR]] | ||
| + | [[Category: Blondiaux N]] | ||
| + | [[Category: Brodin P]] | ||
| + | [[Category: Christophe T]] | ||
| + | [[Category: D prez B]] | ||
| + | [[Category: Desroses M]] | ||
| + | [[Category: Flament MP]] | ||
| + | [[Category: Flipo M]] | ||
| + | [[Category: Jeon HK]] | ||
| + | [[Category: Lecat-Guillet N]] | ||
| + | [[Category: Leroux F]] | ||
| + | [[Category: Locht C]] | ||
| + | [[Category: Mathys V]] | ||
| + | [[Category: Piveteau C]] | ||
| + | [[Category: Siepmann J]] | ||
| + | [[Category: Soror SH]] | ||
| + | [[Category: Villemagne B]] | ||
| + | [[Category: Villeret V]] | ||
| + | [[Category: Willand N]] | ||
| + | [[Category: Wintjens R]] | ||
| + | [[Category: Wohlkonig A]] | ||
Current revision
Ethionamide Boosters Part 2: Combining Bioisosteric Replacement and Structure-Based Drug Design to Solve Pharmacokinetic Issues in a Series of Potent 1,2,4-Oxadiazole EthR Inhibitors.
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Categories: Large Structures | Mycobacterium tuberculosis H37Rv | Baulard AR | Blondiaux N | Brodin P | Christophe T | D prez B | Desroses M | Flament MP | Flipo M | Jeon HK | Lecat-Guillet N | Leroux F | Locht C | Mathys V | Piveteau C | Siepmann J | Soror SH | Villemagne B | Villeret V | Willand N | Wintjens R | Wohlkonig A
