3sk9
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 3sk9 is ON HOLD Authors: Bailey, S, Mulepati, S Description: Crystal structure of the Thermus thermophilus cas3 HD domain) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the Thermus thermophilus cas3 HD domain== | |
| - | + | <StructureSection load='3sk9' size='340' side='right'caption='[[3sk9]], [[Resolution|resolution]] 1.80Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3sk9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus_HB8 Thermus thermophilus HB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SK9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SK9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sk9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sk9 OCA], [https://pdbe.org/3sk9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sk9 RCSB], [https://www.ebi.ac.uk/pdbsum/3sk9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sk9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CAS3_THET8 CAS3_THET8] CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Cas3 plus Cascade participate in CRISPR interference, the third stage of CRISPR immunity. The N-terminal domain (residues 6-260) acts as a ssDNA endonuclease, has no activity on dsDNA.<ref>PMID:21775431</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Thermus thermophilus HB8]] | ||
| + | [[Category: Bailey S]] | ||
| + | [[Category: Mulepati S]] | ||
Current revision
Crystal structure of the Thermus thermophilus cas3 HD domain
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