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3sp6

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[[Image:3sp6.png|left|200px]]
 
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==Structural basis for iloprost as a dual PPARalpha/delta agonist==
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The line below this paragraph, containing "STRUCTURE_3sp6", creates the "Structure Box" on the page.
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<StructureSection load='3sp6' size='340' side='right'caption='[[3sp6]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3sp6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SP6 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IL2:(5E)-5-[(3AS,4R,5R,6AS)-5-HYDROXY-4-[(1E,3S,4R)-3-HYDROXY-4-METHYLOCT-1-EN-6-YN-1-YL]HEXAHYDROPENTALEN-2(1H)-YLIDENE]PENTANOIC+ACID'>IL2</scene></td></tr>
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{{STRUCTURE_3sp6| PDB=3sp6 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sp6 OCA], [https://pdbe.org/3sp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sp6 RCSB], [https://www.ebi.ac.uk/pdbsum/3sp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sp6 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PPARA_HUMAN PPARA_HUMAN] Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety (By similarity). Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2.<ref>PMID:7684926</ref> <ref>PMID:7629123</ref> <ref>PMID:9556573</ref> <ref>PMID:10195690</ref>
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===Structural basis for iloprost as a dual PPARalpha/delta agonist===
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==See Also==
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*[[Peroxisome proliferator-activated receptor 3D structures|Peroxisome proliferator-activated receptor 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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[[3sp6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SP6 OCA].
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Li, Y.]]
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[[Category: Large Structures]]
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[[Category: Rong, H.]]
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[[Category: Li Y]]
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[[Category: Gene transcription]]
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[[Category: Rong H]]
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[[Category: Ligand binding]]
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[[Category: Nuclear receptor fold]]
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[[Category: Ppar lbd]]
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[[Category: Transcription]]
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Current revision

Structural basis for iloprost as a dual PPARalpha/delta agonist

PDB ID 3sp6

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