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3sub

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==Crystal structure of the catalytic domain of Plasmodium falciparum ARF GTPase activating protein==
==Crystal structure of the catalytic domain of Plasmodium falciparum ARF GTPase activating protein==
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<StructureSection load='3sub' size='340' side='right' caption='[[3sub]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
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<StructureSection load='3sub' size='340' side='right'caption='[[3sub]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3sub]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Plasmodium_falciparum_3d7 Plasmodium falciparum 3d7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SUB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SUB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3sub]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SUB FirstGlance]. <br>
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</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene><br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
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<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PFL2140c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=36329 Plasmodium falciparum 3D7])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sub OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sub RCSB], [http://www.ebi.ac.uk/pdbsum/3sub PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sub OCA], [https://pdbe.org/3sub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sub RCSB], [https://www.ebi.ac.uk/pdbsum/3sub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sub ProSAT]</span></td></tr>
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<table>
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</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q8I4Y5_PLAF7 Q8I4Y5_PLAF7]
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The crystal structure of the catalytic domain of the ADP ribosylation factor GTPase-activating protein (ARFGAP) from Plasmodium falciparum has been determined and refined to 2.4 A resolution. Multiwavength anomalous diffraction (MAD) data were collected utilizing the Zn(2+) ion bound at the zinc-finger domain and were used to solve the structure. The overall structure of the domain is similar to those of mammalian ARFGAPs. However, several amino-acid residues in the area where GAP interacts with ARF1 differ in P. falciparum ARFGAP. Moreover, a number of residues that form the dimer interface in the crystal structure are unique in P. falciparum ARFGAP.
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Structure of the catalytic domain of Plasmodium falciparum ARF GTPase-activating protein (ARFGAP).,Cook WJ, Senkovich O, Chattopadhyay D Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Nov 1;67(Pt 11):1339-44., Epub 2011 Oct 25. PMID:22102228<ref>PMID:22102228</ref>
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Plasmodium falciparum 3d7]]
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[[Category: Large Structures]]
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[[Category: Chattopadhyay, D.]]
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[[Category: Plasmodium falciparum 3D7]]
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[[Category: Cook, W J.]]
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[[Category: Chattopadhyay D]]
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[[Category: Gtpase-activating protein]]
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[[Category: Cook WJ]]
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[[Category: Hydrolase activator]]
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[[Category: Protein trafficking]]
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Current revision

Crystal structure of the catalytic domain of Plasmodium falciparum ARF GTPase activating protein

PDB ID 3sub

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