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3tbl

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[[Image:3tbl.jpg|left|200px]]
 
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==Structure of Mono-ubiquitinated PCNA: Implications for DNA Polymerase Switching and Okazaki Fragment Maturation==
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The line below this paragraph, containing "STRUCTURE_3tbl", creates the "Structure Box" on the page.
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<StructureSection load='3tbl' size='340' side='right'caption='[[3tbl]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3tbl]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TBL FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.903&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tbl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tbl OCA], [https://pdbe.org/3tbl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tbl RCSB], [https://www.ebi.ac.uk/pdbsum/3tbl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tbl ProSAT]</span></td></tr>
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{{STRUCTURE_3tbl| PDB=3tbl | SCENE= }}
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PCNA_HUMAN PCNA_HUMAN] Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.<ref>PMID:19443450</ref> <ref>PMID:18719106</ref>
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===Structure of Mono-ubiquitinated PCNA: Implications for DNA Polymerase Switching and Okazaki Fragment Maturation===
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==See Also==
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*[[Proliferating cell nuclear antigen 3D structures|Proliferating cell nuclear antigen 3D structures]]
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*[[3D structures of ubiquitin|3D structures of ubiquitin]]
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==About this Structure==
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== References ==
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[[3tbl]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TBL OCA].
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Lee, E.]]
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[[Category: Large Structures]]
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[[Category: Lee, M.]]
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[[Category: Lee E]]
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[[Category: Zhang, S.]]
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[[Category: Lee M]]
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[[Category: Zhang, Z.]]
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[[Category: Zhang S]]
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[[Category: Pcna]]
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[[Category: Zhang Z]]
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[[Category: Replication]]
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[[Category: Translesion synthesis]]
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[[Category: Ubiquitin]]
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Current revision

Structure of Mono-ubiquitinated PCNA: Implications for DNA Polymerase Switching and Okazaki Fragment Maturation

PDB ID 3tbl

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