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3tnd

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[[Image:3tnd.png|left|200px]]
 
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==Crystal structure of Shigella flexneri VapBC toxin-antitoxin complex==
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The line below this paragraph, containing "STRUCTURE_3tnd", creates the "Structure Box" on the page.
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<StructureSection load='3tnd' size='340' side='right'caption='[[3tnd]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3tnd]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TND OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TND FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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{{STRUCTURE_3tnd| PDB=3tnd | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tnd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tnd OCA], [https://pdbe.org/3tnd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tnd RCSB], [https://www.ebi.ac.uk/pdbsum/3tnd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tnd ProSAT]</span></td></tr>
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</table>
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===Crystal structure of Shigella flexneri VapBC toxin-antitoxin complex===
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== Function ==
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[https://www.uniprot.org/uniprot/VAPC_SHIFL VAPC_SHIFL] Toxic component of a toxin-antitoxin (TA) module. A tRNA-(fMet) endonuclease, it cleaves both charged and uncharged tRNA-(fMet) between positions 38 and 39 at the anticodon stem-loop boundary. Does not cleave tRNA(Met), tRNA(Arg2), tRNA(His), tRNA(Leu), tRNA(Phe) tRNA(Thr1), tRNA(Tyr) or tRNA(Val). Overexpression in E.coli inhibits translation, leads to loss of cell growth and degradation of tRNA(fMet); these effects are neutralized by expression of cognate antitoxin VapB. The VapB/VapC complex probably regulates transcription of its own promoter.<ref>PMID:19400780</ref> <ref>PMID:21502523</ref> Ectopic overexpression in E.coli induces the YoeB toxin, but this is not the cause of VapC toxicity.<ref>PMID:19400780</ref> <ref>PMID:21502523</ref>
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== References ==
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<references/>
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The line below this paragraph, {{ABSTRACT_PUBMED_22037005}}, adds the Publication Abstract to the page
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22037005 is the PubMed ID number.
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</StructureSection>
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[[Category: Large Structures]]
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{{ABSTRACT_PUBMED_22037005}}
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==About this Structure==
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[[3tnd]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Shigella_flexneri Shigella flexneri]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TND OCA].
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==Reference==
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<ref group="xtra">PMID:022037005</ref><references group="xtra"/>
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[[Category: Shigella flexneri]]
[[Category: Shigella flexneri]]
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[[Category: Boggild, A.]]
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[[Category: Boggild A]]
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[[Category: Brodersen, D E.]]
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[[Category: Brodersen DE]]
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[[Category: Dienemann, C.]]
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[[Category: Dienemann C]]
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[[Category: Gerdes, K.]]
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[[Category: Gerdes K]]
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[[Category: Winther, K S.]]
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[[Category: Winther KS]]
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[[Category: Dna-binding]]
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[[Category: Pin domain]]
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[[Category: Ribonuclease]]
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[[Category: Spovt/abrb-like domain]]
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[[Category: Toxin]]
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[[Category: Translation]]
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Current revision

Crystal structure of Shigella flexneri VapBC toxin-antitoxin complex

PDB ID 3tnd

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