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3u2k

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[[Image:3u2k.png|left|200px]]
 
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{{STRUCTURE_3u2k| PDB=3u2k | SCENE= }}
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==S. aureus GyrB ATPase domain in complex with a small molecule inhibitor==
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<StructureSection load='3u2k' size='340' side='right'caption='[[3u2k]], [[Resolution|resolution]] 1.64&Aring;' scene=''>
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===S. aureus GyrB ATPase domain in complex with a small molecule inhibitor===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3u2k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U2K FirstGlance]. <br>
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{{ABSTRACT_PUBMED_22183167}}
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.64&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=087:2-CHLORO-6-(4-{[(3,4-DICHLORO-5-METHYL-1H-PYRROL-2-YL)CARBONYL]AMINO}PIPERIDIN-1-YL)PYRIDINE-4-CARBOXAMIDE'>087</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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==About this Structure==
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u2k OCA], [https://pdbe.org/3u2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u2k RCSB], [https://www.ebi.ac.uk/pdbsum/3u2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u2k ProSAT]</span></td></tr>
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[[3u2k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U2K OCA].
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/GYRB_STAAU GYRB_STAAU] DNA gyrase negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings.[HAMAP-Rule:MF_01898]
==See Also==
==See Also==
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*[[Gyrase|Gyrase]]
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*[[Gyrase 3D Structures|Gyrase 3D Structures]]
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__TOC__
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==Reference==
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</StructureSection>
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<ref group="xtra">PMID:022183167</ref><references group="xtra"/>
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[[Category: Large Structures]]
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
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[[Category: Boriack-Sjodin, P A.]]
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[[Category: Boriack-Sjodin PA]]
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[[Category: Eakin, A E.]]
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[[Category: Eakin AE]]
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[[Category: Prince, D B.]]
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[[Category: Prince DB]]
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[[Category: Sherer, B A.]]
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[[Category: Sherer BA]]
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[[Category: Antimicrobial]]
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[[Category: Atp-binding]]
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[[Category: Isomerase-isomerase inhibitor complex]]
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[[Category: Protein-inhibitor complex]]
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[[Category: Structure-based drug design]]
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Current revision

S. aureus GyrB ATPase domain in complex with a small molecule inhibitor

PDB ID 3u2k

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