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3u44

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[[Image:3u44.png|left|200px]]
 
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==Crystal structure of AddAB-DNA complex==
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The line below this paragraph, containing "STRUCTURE_3u44", creates the "Structure Box" on the page.
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<StructureSection load='3u44' size='340' side='right'caption='[[3u44]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[3u44]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U44 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.201&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
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{{STRUCTURE_3u44| PDB=3u44 | SCENE= }}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u44 OCA], [https://pdbe.org/3u44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u44 RCSB], [https://www.ebi.ac.uk/pdbsum/3u44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u44 ProSAT]</span></td></tr>
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</table>
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===Crystal structure of AddAB-DNA complex===
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== Function ==
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[https://www.uniprot.org/uniprot/ADDA_BACSU ADDA_BACSU] An essential component of the DNA double-stranded break repair machinery, the heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the B.subtilis chi site (5'-AGCGG-3') which transforms the enzyme from a helicase which degrades both DNA strands to one with only 5' -> 3' exonuclease activity. This generates a double-stranded DNA with a protruding 3'-terminated single-stranded tail suitable for the initiation of homologous recombination (chi fragment). The AddA nuclease domain in particular is required for chi fragment generation; this subunit has 3' -> 5' nuclease and helicase activity. RecA thread formation during DNA double-strand break repair requires RecJ or AddAB.<ref>PMID:8387145</ref> <ref>PMID:10756102</ref> <ref>PMID:17570399</ref>
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== References ==
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<references/>
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__TOC__
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(as it appears on PubMed at http://www.pubmed.gov), where 22307084 is the PubMed ID number.
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</StructureSection>
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{{ABSTRACT_PUBMED_22307084}}
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==About this Structure==
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[[3u44]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U44 OCA].
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==Reference==
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<ref group="xtra">PMID:022307084</ref><references group="xtra"/>
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[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
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[[Category: Krajewski, W.]]
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[[Category: Large Structures]]
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[[Category: Saikrishnan, K.]]
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[[Category: Krajewski W]]
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[[Category: Wigley, D.]]
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[[Category: Saikrishnan K]]
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[[Category: Dna repair]]
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[[Category: Wigley D]]
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[[Category: Helicase]]
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[[Category: Hydrolase-dna complex]]
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[[Category: Nuclease]]
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[[Category: Protein-dna complex]]
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Current revision

Crystal structure of AddAB-DNA complex

PDB ID 3u44

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OCA

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