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3ub6

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==Periplasmic portion of the Helicobacter pylori chemoreceptor TlpB with urea bound==
==Periplasmic portion of the Helicobacter pylori chemoreceptor TlpB with urea bound==
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<StructureSection load='3ub6' size='340' side='right' caption='[[3ub6]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
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<StructureSection load='3ub6' size='340' side='right'caption='[[3ub6]], [[Resolution|resolution]] 1.38&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3ub6]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Helicobacter_pylori_ss1 Helicobacter pylori ss1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UB6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3UB6 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3ub6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_pylori_SS1 Helicobacter pylori SS1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UB6 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.38&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3ub7|3ub7]], [[3ub8|3ub8]], [[3ub9|3ub9]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=URE:UREA'>URE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ub6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ub6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ub6 RCSB], [http://www.ebi.ac.uk/pdbsum/3ub6 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ub6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ub6 OCA], [https://pdbe.org/3ub6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ub6 RCSB], [https://www.ebi.ac.uk/pdbsum/3ub6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ub6 ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/B6JPK4_HELP2 B6JPK4_HELP2]
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pH sensing is crucial for survival of most organisms, yet the molecular basis of such sensing is poorly understood. Here, we present an atomic resolution structure of the periplasmic portion of the acid-sensing chemoreceptor, TlpB, from the gastric pathogen Helicobacter pylori. The structure reveals a universal signaling fold, a PAS domain, with a molecule of urea bound with high affinity. Through biophysical, biochemical, and in vivo mutagenesis studies, we show that urea and the urea-binding site residues play critical roles in the ability of H. pylori to sense acid. Our signaling model predicts that protonation events at Asp114, affected by changes in pH, dictate the stability of TlpB through urea binding.
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Structure and Proposed Mechanism for the pH-Sensing Helicobacter pylori Chemoreceptor TlpB.,Goers Sweeney E, Henderson JN, Goers J, Wreden C, Hicks KG, Foster JK, Parthasarathy R, Remington SJ, Guillemin K Structure. 2012 Jun 14. PMID:22705207<ref>PMID:22705207</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Helicobacter pylori ss1]]
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[[Category: Helicobacter pylori SS1]]
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[[Category: Goers, J]]
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[[Category: Large Structures]]
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[[Category: Guillemin, K J]]
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[[Category: Goers J]]
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[[Category: Henderson, J N]]
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[[Category: Guillemin KJ]]
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[[Category: Hicks, K G]]
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[[Category: Henderson JN]]
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[[Category: Parthasarathy, R]]
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[[Category: Hicks KG]]
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[[Category: Remington, S J]]
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[[Category: Parthasarathy R]]
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[[Category: Sweeney, E G]]
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[[Category: Remington SJ]]
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[[Category: Wreden, C]]
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[[Category: Sweeney EG]]
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[[Category: Four-helix bundle]]
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[[Category: Wreden C]]
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[[Category: Homodimer]]
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[[Category: Membrane protein]]
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[[Category: Pas domain]]
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Current revision

Periplasmic portion of the Helicobacter pylori chemoreceptor TlpB with urea bound

PDB ID 3ub6

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