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3ue8

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[[Image:3ue8.png|left|200px]]
 
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{{STRUCTURE_3ue8| PDB=3ue8 | SCENE= }}
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==Kynurenine Aminotransferase II Inhibitors==
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<StructureSection load='3ue8' size='340' side='right'caption='[[3ue8]], [[Resolution|resolution]] 3.22&Aring;' scene=''>
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===Kynurenine Aminotransferase II Inhibitors===
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== Structural highlights ==
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<table><tr><td colspan='2'>[[3ue8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UE8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UE8 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.22&#8491;</td></tr>
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==About this Structure==
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=09M:(5-HYDROXY-4-{[(1-HYDROXY-2-OXO-1,2-DIHYDROQUINOLIN-3-YL)AMINO]METHYL}-6-METHYLPYRIDIN-3-YL)METHYL+DIHYDROGEN+PHOSPHATE'>09M</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr>
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[[3ue8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UE8 OCA].
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ue8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ue8 OCA], [https://pdbe.org/3ue8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ue8 RCSB], [https://www.ebi.ac.uk/pdbsum/3ue8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ue8 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Anderson, M.]]
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[[Category: Large Structures]]
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[[Category: Bechle, B M.]]
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[[Category: Anderson M]]
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[[Category: Campbell, B M.]]
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[[Category: Bechle BM]]
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[[Category: Claffey, M M.]]
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[[Category: Campbell BM]]
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[[Category: Dounay, A B.]]
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[[Category: Claffey MM]]
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[[Category: Edelweiss, E.]]
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[[Category: Dounay AB]]
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[[Category: Evdokimov, A.]]
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[[Category: Edelweiss E]]
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[[Category: Fonseca, K R.]]
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[[Category: Evdokimov A]]
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[[Category: Gan, X.]]
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[[Category: Fonseca KR]]
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[[Category: Ghosh, S.]]
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[[Category: Gan X]]
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[[Category: Hayward, M M.]]
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[[Category: Ghosh S]]
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[[Category: Horner, W.]]
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[[Category: Hayward MM]]
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[[Category: Kim, J Y.]]
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[[Category: Horner W]]
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[[Category: McAllister, L A.]]
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[[Category: Kim JY]]
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[[Category: Pandit, J.]]
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[[Category: McAllister LA]]
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[[Category: Paradis, V.]]
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[[Category: Pandit J]]
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[[Category: Parikh, V D.]]
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[[Category: Paradis V]]
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[[Category: Reese, M R.]]
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[[Category: Parikh VD]]
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[[Category: Rong, S B.]]
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[[Category: Reese MR]]
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[[Category: Salafia, M A.]]
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[[Category: Rong SB]]
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[[Category: Schuyten, K.]]
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[[Category: Salafia MA]]
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[[Category: Strick, C A.]]
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[[Category: Schuyten K]]
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[[Category: Tuttle, J B.]]
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[[Category: Strick CA]]
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[[Category: Valentine, J.]]
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[[Category: Tuttle JB]]
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[[Category: Verhoest, P R.]]
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[[Category: Valentine J]]
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[[Category: Wang, H.]]
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[[Category: Verhoest PR]]
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[[Category: Zawadzke, L E.]]
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[[Category: Wang H]]
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[[Category: Kat ii]]
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[[Category: Zawadzke LE]]
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[[Category: Kynurenine aminotransferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Kynurenine Aminotransferase II Inhibitors

PDB ID 3ue8

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