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3un9
From Proteopedia
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| - | [[Image:3un9.jpg|left|200px]] | ||
| - | + | ==Crystal structure of an immune receptor== | |
| - | + | <StructureSection load='3un9' size='340' side='right'caption='[[3un9]], [[Resolution|resolution]] 2.65Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[3un9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3UN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3UN9 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65Å</td></tr> | |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PT:PLATINUM+(II)+ION'>PT</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3un9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3un9 OCA], [https://pdbe.org/3un9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3un9 RCSB], [https://www.ebi.ac.uk/pdbsum/3un9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3un9 ProSAT]</span></td></tr> | |
| - | + | </table> | |
| - | + | == Function == | |
| - | + | [https://www.uniprot.org/uniprot/NLRX1_HUMAN NLRX1_HUMAN] Participates in antiviral signaling. Acts as a negative regulator of MAVS-mediated antiviral responses, through the inhibition of the virus-induced RLH (RIG-like helicase)-MAVS interaction (PubMed:18200010). Has no inhibitory function on NF-Kappa-B and type 1 interferon signaling pathways, but enhances NF-Kappa-B and JUN N-terminal kinase dependent signaling through the production of reactive oxygen species (PubMed:18219313).<ref>PMID:18219313</ref> <ref>PMID:18200010</ref> | |
| - | + | == References == | |
| - | < | + | <references/> |
| - | + | __TOC__ | |
| - | + | </StructureSection> | |
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| - | [[3un9]] is a 3 chain structure with sequence from [ | + | |
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Hong M]] |
| - | [[Category: | + | [[Category: Wilson IA]] |
| - | [[Category: | + | [[Category: Yoon SI]] |
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Current revision
Crystal structure of an immune receptor
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